The investigation and management of chronic neutropenia in children

被引：33
作者：
James, R. M.
Kinsey, S. E.
机构：
[1] St James Univ Hosp, Childrens Day Hosp, Dept Paediat Haematol & Oncol, Leeds LS9 7TF, W Yorkshire, England
[2] Univ York, Dept Hlth Sci, Epidemiol & Genet Unit, York YO10 5DD, N Yorkshire, England
来源：
ARCHIVES OF DISEASE IN CHILDHOOD | 2006年 / 91卷 / 10期
关键词：
D O I：
10.1136/adc.2006.094706
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Unravelling the cause of a neutropenia poses a complex diagnostic challenge. The differential diagnosis ranges from life threatening disease to transient benign causes of little clinical significance. This review offers a practical guide to investigating the neutropenic child, and highlights features that merit specialist referral. Therapeutic options, the role of long term follow up, and the complications of severe chronic neutropenia are considered.
引用
收藏
页码：852 / 858
页数：7
相关论文
共 38 条
[1]   Allogeneic stem cell transplantation for patients with congenital amegakaryocytic thrombocytopenia (CAT) [J].
Al-Ahmari, A ;
Ayas, M ;
Al-Jefri, A ;
Al-Mahr, M ;
Rifai, S ;
El Solh, H .
BONE MARROW TRANSPLANTATION, 2004, 33 (08) :829-831
[2]   Bone marrow failure syndromes in children [J].
Alter, BP .
PEDIATRIC CLINICS OF NORTH AMERICA, 2002, 49 (05) :973-+
[3]   RETRACTED: Impaired survival of bone marrow hematopoietic progenitor cells in cyclic neutropenia (Retracted Article) [J].
Aprikyan, AAG ;
Liles, WC ;
Rodger, E ;
Jonas, M ;
Chi, EY ;
Dale, DC .
BLOOD, 2001, 97 (01) :147-153
[4]   LONG-TERM SAFETY OF TREATMENT WITH RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR (R-METHUG-CSF) IN PATIENTS WITH SEVERE CONGENITAL NEUTROPENIAS [J].
BONILLA, MA ;
DALE, D ;
ZEIDLER, C ;
LAST, L ;
REITER, A ;
RUGGEIRO, M ;
DAVIS, M ;
KOCI, B ;
HAMMOND, W ;
GILLIO, A ;
WELTE, K .
BRITISH JOURNAL OF HAEMATOLOGY, 1994, 88 (04) :723-730
[5]   EFFECTS OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR ON NEUTROPENIA IN PATIENTS WITH CONGENITAL AGRANULOCYTOSIS [J].
BONILLA, MA ;
GILLIO, AP ;
RUGGEIRO, M ;
KERNAN, NA ;
BROCHSTEIN, JA ;
ABBOUD, M ;
FUMAGALLI, L ;
VINCENT, M ;
GABRILOVE, JL ;
WELTE, K ;
SOUZA, LM ;
OREILLY, RJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (24) :1574-1580
[6]  
Boxer L, 1995, BLOOD, V86, P2020
[7]   Diagnosis and clinical course of autoimmune neutropenia in infancy: Analysis of 240 cases [J].
Bux, J ;
Behrens, G ;
Jaeger, G ;
Welte, K .
BLOOD, 1998, 91 (01) :181-186
[8]   Stem cell transplantation in patients with severe congenital neutropenia with evidence of leukemic transformation [J].
Choi, SW ;
Boxer, LA ;
Pulsipher, MA ;
Roulston, D ;
Hutchinson, RJ ;
Yanik, GA ;
Cooke, KR ;
Ferrara, JLM ;
Levine, JE .
BONE MARROW TRANSPLANTATION, 2005, 35 (05) :473-477
[9]   Risk and benefit of treatment of severe chronic neutropenia with granulocyte colony-stimulating factor [J].
Cottle, TE ;
Fier, CJ ;
Donadieu, J ;
Kinsey, SE .
SEMINARS IN HEMATOLOGY, 2002, 39 (02) :134-140
[10]   Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia [J].
Dale, DC ;
Person, RE ;
Bolyard, AA ;
Aprikyan, AG ;
Bos, C ;
Bonilla, MA ;
Boxer, LA ;
Kannourakis, G ;
Zeidler, C ;
Welte, K ;
Benson, KF ;
Horwitz, M .
BLOOD, 2000, 96 (07) :2317-2322
1234