Discovery of anticancer agents of diverse natural origin

被引：71

作者：

Kinghorn, A. Douglas ^{[1
]}

de Blanco, Esperanza J. Carcache ^{[1
]}

Chail, Hee-Byung ^{[1
]}

Orjala, Jimmy ^{[2
]}

Farnsworth, Norman R. ^{[2
]}

Soejarto, D. Doel ^{[2
]}

Oberlies, Nicholas H. ^{[3
]}

Wani, Mansukh C. ^{[3
]}

Kroll, David J. ^{[3
]}

Pearce, Cedric J. ^{[4
]}

Swanson, Steven M. ^{[2
]}

Kramer, Robert A. ^{[5
]}

Rose, William C. ^{[5
]}

Fairchild, Craig R. ^{[5
]}

Vite, Gregory D. ^{[5
]}

Emanuel, Stuart ^{[5
]}

Jarjoura, David ^{[6
]}

Cope, Frederick O. ^{[6
]}

机构：

[1] Ohio State Univ, Coll Pharm, Columbus, OH 43210 USA

[2] Univ Illinois, Coll Pharm, Chicago, IL 60612 USA

[3] Res Triangle Inst, Res Triangle Pk, NC 27709 USA

[4] Mycosynthetix Inc, Hillsborough, NC 27278 USA

[5] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA

[6] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

PURE AND APPLIED CHEMISTRY | 2009年 / 81卷 / 06期

关键词：

natural products; plants; cyanobacteria; fungi; anticancer activity; NF-KAPPA-B; PRODUCT-DERIVED COMPOUNDS; ENANTIOSELECTIVE SYNTHESIS; DRUG DISCOVERY; ACULEATIN-A; ROCAGLAMIDE DERIVATIVES; ABSOLUTE-CONFIGURATIONS; PROTEASOME INHIBITION; FUNGAL METABOLITE; CANCER;

D O I：

10.1351/PAC-CON-08-10-16

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which crude extracts of these acquisitions are tested. Progress made in the isolation of lead bioactive secondary metabolites from three tropical plants is discussed.

引用

页码：1051 / 1063

页数：13

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