The effect of RAD51 135 G>C and XRCC2 G>A (rs3218536) polymorphisms on ovarian cancer risk among Caucasians: a meta-analysis

被引：10

作者：

Shi, Shujing ^{[1
]}

Qin, Lingyan ^{[2
]}

Tian, Mengqiu ^{[1
]}

Xie, Mao ^{[1
]}

Li, Xiaoxue ^{[1
]}

Qi, Chenglin ^{[1
]}

Yi, Xiang ^{[1
]}

机构：

[1] Guangxi Med Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Hosp 1, Nanning 530021, Guangxi, Peoples R China

[2] Guangxi Med Univ, Dept Clin Lab, Affiliated Hosp 1, Nanning 530021, Guangxi, Peoples R China

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 06期

关键词：

RAD51; XRCC2; Polymorphism; Ovarian cancer; Meta-analysis; SINGLE NUCLEOTIDE POLYMORPHISM; SURFACE EPITHELIAL-CELLS; DNA-REPAIR GENES; BREAST-CANCER; RAD51; XRCC2; ASSOCIATION; OVULATION; REGION; RECOMBINATION;

D O I：

10.1007/s13277-014-1769-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genetic polymorphisms of RAD51 135 G > C and XRCC2 G > A (rs3218536) have been reported to change the risk of ovarian cancer, but the results are controversial. To get a more precise result, a meta-analysis was performed. A comprehensive literature search in PubMed, Excerpta Medica Database, and China National Knowledge Infrastructure was carried out to get case-control studies published up to November 2013. The pooled odds ratio (OR) and its corresponding 95 % confidence interval (CI) were conducted to estimate the effect of RAD51 135 G > C and XRCC2 G > A (rs3218536) polymorphisms on ovarian cancer risk. A total of 13 independent case-control studies with 5,927 cases and 10,303 controls were included in this meta-analysis. There was no significant association between RAD51 135 G > C polymorphism and risk of ovarian cancer. However, the result of total studies indicated the XRCC2 G > A (rs3218536) polymorphism could reduce the risk of ovarian cancer (heterozygote model AG vs. GG: OR = 0.877, 95 % CI = 0.770-0.999, P = 0.048; dominant model AA/AG vs. GG: OR = 0.864, 95 % CI = 0.763-0.979, P = 0.022). The result was still significant after Hardy-Weinberg equilibrium-violating studies were excluded (allele contrast A vs. G: OR = 0.836, 95 % CI = 0.74-0.943, P = 0.004; homozygote model AA vs. GG: OR = 0.562, 95 % CI = 0.317-0.994, P = 0.048; heterozygote model AG vs. GG: OR = 0.859, 95 % CI = 0.753-0.98, P = 0.023; dominant model AA/AG vs. GG: OR = 0.842, 95 % CI = 0.74-0.958, P = 0.009). In the stratified analysis by ethnicity, significantly reduced risk was observed among Caucasians in dominant model (AA/AG vs. GG: OR = 0.867, 95 % CI = 0.764-0.984, P = 0.027). No significant association was found between the RAD51 135G > C polymorphism and the risk of ovarian cancer. Interestingly, XRCC2 G > A (rs3218536) polymorphism might reduce the risk of ovarian cancer. Larger-scale and well-designed studies are needed to further clarify the association.

引用

页码：5797 / 5804

页数：8

共 36 条

[1] Meta-analyses of molecular association studies: Methodologic lessons for genetic epidemiology [J].