Getting to know protein kinase D

被引：42

作者：

Van Lint, J ^{[1
]}

Rykx, A ^{[1
]}

Vantus, T ^{[1
]}

Vandenheede, JR ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Fac Med, Div Biochem, B-3000 Louvain, Belgium

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2002年 / 34卷 / 06期

关键词：

protein kinase; growth factor signalling; apoptosis; second messengers;

D O I：

10.1016/S1357-2725(01)00163-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protein kinase D (PKD) enzymes represent a new family of second messenger stimulated kinases, with diacylglycerol as a prime, but not the sole, mediator of activation. Their molecular architecture features a catalytic domain, unrelated to that of all PKC family members, and a large inhibitory, regulatory domain, comprised of two Zinc fingers, and a pleckstrin homology domain. These different sub-domains play distinctive roles in the activation, translocation and biological functions of the kinase. The enzymes have been implicated in signalling mechanisms controlling cell proliferation and programmed cell death and in metastasis, immune responses, and Golgi restructuring and function. A variety of proteins specifically interact with the different sub-domains of the enzymes and direct their wide range of cellular functions. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：577 / 581

页数：5

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