Nuciferine alleviates acute alcohol-induced liver injury in mice: Roles of suppressing hepatic oxidative stress and inflammation via modulating miR-144/Nrf2/HO-1 cascade

被引:26
|
作者
Shu, Guangwen [1 ,2 ]
Qiu, Yunhan [1 ]
Hao, Ji [1 ]
Fu, Qian [1 ]
Deng, Xukun [1 ,2 ]
机构
[1] South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
[2] South Cent Univ Nationalities, Natl Demonstrat Ctr Expt Ethnopharmacol Educ, Wuhan 430074, Hubei, Peoples R China
关键词
Nuciferine; Acute alcohol-induced liver injury; Nrf2/HO-1; pathway; MiR-144; HEME OXYGENASE-1; PROTECTIVE ROLE; ETHANOL; ACTIVATION; EXPRESSION; APOPTOSIS; CELLS; STEATOSIS; PATHWAY;
D O I
10.1016/j.jff.2019.04.055
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Binge consumption of alcohol results in severe global health problem. This study aimed to explore the potential efficacy of nuciferine (NCF) in protecting acute alcohol-induced liver injury and the underlying molecular mechanisms. We revealed that NCF activated Nrf2/HO-1 signaling in HepG2 hepatocytes and relieved alcoholinduced ROS generation and subsequent cell death. Mechanistically, suppression of miR-144 expression contributed to NCF-mediated activation of Nrf2/HO-1 signaling. Consistently, NCF modulated hepatic miR-144/ Nrf2/HO-1 axis and alleviated acute alcohol-induced liver injury as well as concomitant oxidative stress and inflammation in mice. In addition, suppressing the catalytic activity of HO-1 by ZnPP, an inhibitor of HO-1, diminished the hepatoprotective effects of NCF. The ameliorative effects of NCF on acute alcohol-provoked hepatic oxidative stress and inflammation were also crippled by ZnPP. Taken together, our data suggested that NCF is able to relive acute alcohol-induced liver injury and modulating miR-144/Nrf2/HO-1 cascade is implicated in the hepatoprotective activity of NCF.
引用
收藏
页码:105 / 113
页数:9
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