One-pot synthesis and functionalisation of Fe2O3@C-NH2 nanoparticles for imaging and therapy

被引：3
|
作者：
Li, Xiaofeng [1 ,2 ,4 ,5 ]
Ding, Jiabao [2 ,5 ]
Wang, Xiaofeng [2 ,5 ]
Wei, Kai [2 ,5 ]
Weng, Jian [2 ,5 ]
Wang, Jinan [3 ,6 ]
机构：
[1] Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China
[2] Xiamen Univ, Dept Biomaterials, Coll Mat, Xiamen 361005, Peoples R China
[3] Xiamen Univ, Zhongshan Hosp, Dept Imaging, Xiamen 361005, Peoples R China
[4] Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China
[5] Xiamen Univ, Dept Biomat, Coll Mat, Xiamen 361005, Peoples R China
[6] Xiamen Univ, Zhongshan Hosp, Dept Imaging, Xiamen 361005, Peoples R China
来源：
IET NANOBIOTECHNOLOGY | 2014年 / 8卷 / 02期
关键词：
biomedical materials; biomedical MRI; biothermics; cancer; carbon; catalysts; cellular biophysics; decomposition; iron compounds; nanofabrication; nanoparticles; nitrogen compounds; particle size; patient treatment; polymers; solubility; nanomedicine; Fe2O3-C-NH2; size; 20; nm; time; 48; h; temperature; 180; degC; cancer thermal therapy; magnetic resonance imaging; functionalised core-shell nanoparticles; cancer cells; aqueous solution; folic acid; polyethylene glycol; amino group; nanoparticle size; surface functionalisation group; perchlorinated pyrene; cocatalyst; solvothermal conditions; ammonia; amine-modified nanoparticles; one-pot synthesis; IRON-OXIDE NANOPARTICLES; MAGNETIC NANOPARTICLES; CELLULAR UPTAKE; CARBON; CARBONIZATION; DECOMPOSITION; HYPERTHERMIA; PARTICLES; CATALYSTS; SIZE;
D O I：
10.1049/iet-nbt.2012.0015
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The authors have prepared amine-modified Fe2O3@C nanoparticles with diameter of 20 nm by decomposing perchlorinated pyrene/Fe(NO3)(3) mixture in the presence of ammonia in solvothermal conditions at 180 degrees C for 48 h by a one-step process. NH3 is not only a cocatalyst of Fe(NO3)(3) for decomposition of perchlorinated pyrene, but also the source of surface functionalisation group. The effect of synthesis conditions on shape and size of nanoparticles and characterisation of their structure and functionalisation group are investigated in this research. The amino group in the surface of core-shell nanoparticles can be further functionalised with polyethylene glycol and folic acid to improve their solubility in aqueous solution and target cancer cells. The applications of functionalised core-shell nanoparticles in magnetic resonance imaging and cancer thermal therapy are also investigated in this research.
引用
收藏
页码：93 / 101
页数：9
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