Transport of L-Arginine Related Cardiovascular Risk Markers

被引：28

作者：

Banjarnahor, Sofna ^{[1
,2
]}

Rodionov, Roman N. ^{[3
,4
,5
]}

Konig, Jorg ^{[1
]}

Maas, Renke ^{[1
]}

机构：

[1] Friedrich Alexander Univ Erlangen Nurnberg, Inst Expt & Clin Pharmacol & Toxicol, D-91504 Erlangen, Germany

[2] Indonesian Inst Sci LIPI, Res Ctr Chem, Kawasan PUSPIPTEK Serpong, Tangerang Selatan 15314, Banten, Indonesia

[3] Tech Univ Dresden, Univ Ctr Vasc Med, Dept Internal Med 3, Div Angiol, D-01307 Dresden, Germany

[4] Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, SA 5042, Australia

[5] Flinders Med Ctr, Adelaide, SA 5042, Australia

来源：

JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 12期

关键词：

transport; L-arginine; ADMA; SDMA; L-homoarginine; AMINO-ACID TRANSPORTER; NITRIC-OXIDE SYNTHASE; ASYMMETRIC DIMETHYLARGININE ADMA; HYPERAMMONEMIA-HOMOCITRULLINURIA SYNDROME; MITOCHONDRIAL ORNITHINE TRANSPORTER; ORGANIC CATION TRANSPORTER; HUMAN ENDOTHELIAL-CELLS; CULTURED ANIMAL-CELLS; P-GLYCOPROTEIN; FUNCTIONAL-CHARACTERIZATION;

D O I：

10.3390/jcm9123975

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

L-arginine and its derivatives, asymmetric and symmetric dimethylarginine (ADMA and SDMA) and L-homoarginine, have emerged as cardiovascular biomarkers linked to cardiovascular outcomes and various metabolic and functional pathways such as NO-mediated endothelial function. Cellular uptake and efflux of L-arginine and its derivatives are facilitated by transport proteins. In this respect the cationic amino acid transporters CAT1 and CAT2 (SLC7A1 and SLC7A2) and the system y(+)L amino acid transporters (SLC7A6 and SLC7A7) have been most extensively investigated, so far, but the number of transporters shown to mediate the transport of L-arginine and its derivatives is constantly increasing. In the present review we assess the growing body of evidence regarding the function, expression, and clinical relevance of these transporters and their possible relation to cardiovascular diseases.

引用

页数：41

共 280 条

[1] CAT-1-Mediated Arginine Uptake and Regulation of Nitric Oxide Synthases for the Survival of Human Breast Cancer Cell Lines [J].