Heat preconditioning attenuates renal injury in ischemic ARF in rats:: Role of heat-shock protein 70 on NF-κB-mediated inflammation and on tubular cell injury

被引:49
|
作者
Jo, Sang-Kyung [1 ]
Ko, Gang Jee [1 ]
Boo, Chang Su [1 ]
Cho, Won Yong [1 ]
Kim, Hyoung Kyu [1 ]
机构
[1] Korea Univ Hosp, Inst Renal Dis, Dept Internal Med, Div Nephrol, Seoul 136705, South Korea
来源
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2006年 / 17卷 / 11期
关键词
D O I
10.1681/ASN.2005101077
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Although heat preconditioning has been known to be protective in various types of injury, the precise molecular mechanism for this is unclear. Recent observations that indicate that previous heat shock has an anti-inflammatory, antiapoptotic effect led to this investigation of the in vivo effect of heat preconditioning on NF-kappa B activation and inflammation and also on tubular cell injury in ischemic acute renal failure (ARF). Heat preconditioning provided marked functional protection and also reduced histologic evidence of tubular necrosis. Ischemia/reperfusion-induced NF-kappa B activation was suppressed by heat preconditioning with a subsequent decrease in monocyte chemoattractant protein-1 expression and inflammatory cell infiltration. Heat preconditioning also suppressed the accumulation of phosphorylated inhibitory kappa B alpha (I kappa B alpha) with a resultant depletion of cytoplasmic I kappa B alpha, indicating that heat preconditioning blocked the activation of the I kappa B kinase complex. Tubular cell apoptosis, determined by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling staining, also was decreased by heat preconditioning, and this was accompanied by decreased caspase 3 activation. Among several heat-shock proteins (HSP), HSP-70 was induced primarily by heat preconditioning. Inhibition of HSP-70 by quercetin almost completely reversed the functional protection that was provided by heat preconditioning. These data provide evidence that HSP-70 affords protection via inhibition of NF-kappa B-mediated inflammation and also inhibition of the cell death pathway in ischemic ARE Further elucidation of the cytoprotective mechanism of stress proteins could facilitate new target or drug development in the treatment of ARF.
引用
收藏
页码:3082 / 3092
页数:11
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