COVID-19 in children across three Asian cosmopolitan regions

被引：23

作者：

Chua, Gilbert T. ^{[1
]}

Xiong, Xiaoli ^{[2
]}

Choi, Eun Hwa ^{[3
]}

Han, Mi Seon ^{[4
]}

Chang, Sung Hee ^{[5
]}

Jin, Byoung Lo ^{[6
]}

Lee, Eun Joo ^{[7
]}

Kim, Baek Nam ^{[8
]}

Kim, Min Kyoung ^{[9
]}

Doo, Kihyun ^{[10
]}

Seo, Ju Hee ^{[11
]}

Kim, Yae Jean ^{[12
]}

Kim, Yeo Jin ^{[13
]}

Park, Ji Young ^{[14
]}

Suh, Sun Bok ^{[15
]}

Lee, Hyunju ^{[16
]}

Cho, Eun Young ^{[17
]}

Kim, Dong Hyun ^{[18
]}

Kim, Jong Min ^{[19
]}

Kim, Hye Young ^{[20
]}

Park, Su Eun ^{[21
]}

Lee, Joon Kee ^{[22
]}

Jo, Dae Sun ^{[23
]}

Cho, Seung Man ^{[24
]}

Choi, Jae Hong ^{[25
]}

Jo, Kyo Jin ^{[21
]}

Choe, Young June ^{[26
]}

Kim, Ki Hwan ^{[27
]}

Chi, Shuiqing ^{[28
]}

Tang, Shao-tao ^{[28
]}

Qin, Huan ^{[29
,30
]}

Zhou, Li Shan ^{[2
]}

Chen, Peng ^{[31
]}

Wong, Joshua Sung Chih ^{[32
]}

Chan, Kate Ching Ching ^{[33
]}

Yau, Felix Yat Sun ^{[34
]}

Lam, Shu Yan ^{[35
]}

Chow, Calvin Chit Kwong ^{[36
]}

Wong, Tak Wai ^{[37
]}

Chan, Victor Chi-man ^{[38
]}

Poon, Grace Wing Kit ^{[1
,39
]}

Chow, Chun Bong ^{[1
,32
]}

Wong, Wilfred H. S. ^{[1
]}

Lau, Yu Lung ^{[1
]}

Chan, Godfrey Chi Fung ^{[1
]}

Chui, Celine S. L. ^{[1
,40
]}

Li, Xue ^{[40
,41
]}

Ho, Marco Hok Kung ^{[1
]}

Wong, Ian C. K. ^{[40
,42
]}

Tam, Paul Kwong Hang ^{[43
,44
]}

机构：

[1] Univ Hong Kong, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Integrated Chinese & Western Med, Wuhan Childrens Hosp,Wuhan Maternal & Child Healt, Wuhan, Peoples R China

[3] Seoul Natl Univ, Coll Med, Dept Pediat, Seoul, South Korea

[4] Seoul Natl Univ, Seoul Metropolitan Govt, Boramae Med Ctr, Dept Pediat, Seoul, South Korea

[5] Seoul Med Ctr, Dept Pediat, Seoul, South Korea

[6] Hongseong Med Ctr, Dept Pediat, Hongseong, South Korea

[7] Seongnam Citizens Med Ctr, Dept Pediat, Seongnam, South Korea

[8] Gyeonggi Prov Med Ctr Ansung Hosp, Dept Pediat, Ansung, South Korea

[9] Seonam Hosp, Dept Pediat, Seoul, South Korea

[10] Gyeonggi Prov Med Ctr Icheon Hosp, Dept Pediat, Icheon, South Korea

[11] Dankook Univ Hosp, Dept Pediat, Cheonan, South Korea

[12] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, Seoul, South Korea

[13] Masan Med Ctr, Dept Pediat, Chang Won, South Korea

[14] Chung Ang Univ Hosp, Dept Pediat, Seoul, South Korea

[15] Busan Med Ctr, Dept Pediat, Busan, South Korea

[16] Seoul Natl Univ, Dept Pediat, Bundang Hosp, Seongnam, South Korea

[17] Chungnam Natl Univ Hosp, Dept Pediat, Daejeon, South Korea

[18] Inha Univ Hosp, Dept Pediat, Incheon, South Korea

[19] Myongji Hosp, Dept Pediat, Goyang, South Korea

[20] Pusan Natl Univ Hosp, Dept Pediat, Busan, South Korea

[21] Pusan Natl Univ, Dept Pediat, Childrens Hosp, Yangsan, South Korea

[22] Chungbuk Natl Univ Hosp, Dept Pediat, Cheongju, South Korea

[23] Jeonbuk Natl Univ, Dept Pediat, Sch Med, Jeonju, South Korea

[24] Dongguk Univ, Dept Pediat, Coll Med, Gyeongju, South Korea

[25] Jeju Natl Univ Hosp, Dept Pediat, Jeju, South Korea

[26] Hallym Univ, Coll Med, Dept Social & Prevent Med, Chunchon, South Korea

[27] Catholic Univ Korea, Dept Pediat, Incheon St Marys Hosp, Incheon, South Korea

[28] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Pediat Surg, Wuhan, Peoples R China

[29] Huazhong Univ Sci & Technol, Wuhan, Peoples R China

[30] Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Maternal & Child Hlth, Wuhan Childrens Hosp,Wuhan Maternal & Child Healt, Wuhan, Peoples R China

[31] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Resp Med, Wuhan Childrens Hosp,Wuhan Maternal & Child Healt, Wuhan, Peoples R China

[32] Princess Margaret Hosp, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[33] Chinese Univ Hong Kong, Fac Med, Dept Pediat, Hong Kong, Peoples R China

[34] Queen Elizabeth Hosp, Dept Pediat, Hong Kong, Peoples R China

[35] Tuen Mun Hosp, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[36] United Christian Hosp, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[37] Alice Ho Miu Ling Nethersole Hosp, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[38] Pamela Youle Nethersole Eastern Hosp, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[39] Queen Mary Hosp, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[40] Univ Hong Kong, Dept Pharmacol & Pharm, Ctr Safe Medicat Practice & Res, Hong Kong, Peoples R China

[41] Univ Hong Kong, Dept Pediat, Hong Kong, Peoples R China

[42] UCL, UCL Sch Pharm, Res Dept Practice & Policy, London, England

[43] Univ Hong Kong, Dept Surg, Dept Paediat Surg, Hong Kong, Peoples R China

[44] Univ Hong Kong, Inst Collaborat Regenerat Med, Univ Hong Kong Karolinska, Dr Li Dak Sum Res Ctr, Hong Kong, Peoples R China

[45] Univ Hong Kong, Li Ka Shing Fac Med, Carol Yu Ctr Infect, Dept Microbiol, Hong Kong, Peoples R China

[46] Catholic Univ Korea, St Vincents Hosp, Dept Pediat, Suwon, South Korea

来源：

EMERGING MICROBES & INFECTIONS | 2020年 / 9卷 / 01期

关键词：

COVID-19; Asia; children; travel history; age-stratified; CORONAVIRUS; DISEASE;

D O I：

10.1080/22221751.2020.1846462

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As another wave of COVID-19 outbreak has approached in July 2020, a larger scale COVID-19 pediatric Asian cohort summarizing the clinical observations is warranted. Children confirmed with COVID-19 infection from the Republic of Korea, the Hong Kong Special Administrative Region (HKSAR) and Wuhan, China, during their first waves of local outbreaks were included. Their clinical characteristics and the temporal sequences of the first waves of local paediatric outbreaks were compared. Four hundred and twenty three children with COVID-19 were analyzed. Wuhan had the earliest peak, followed by Korea and HKSAR. Compared with Korea and Wuhan, patients in HKSAR were significantly older (mean age: 12.9 vs. 10.8 vs. 6.6 years, p < 0.001, respectively) and had more imported cases (87.5% vs. 16.5% vs. 0%, p < 0.001, respectively). The imported cases were also older (13.4 vs. 7.6 years, p < 0.001). More cases in HKSAR were asymptomatic compared to Korea and Wuhan (45.5% vs. 22.0% vs. 20.9%, p < 0.001, respectively), and significantly more patients from Wuhan developed fever (40.6% vs. 29.7% vs. 21.6%, p=0.003, respectively). There were significantly less imported cases than domestic cases developing fever after adjusting for age and region of origin (p = 0.046). 5.4% to 10.8% of patients reported anosmia and ageusia. None developed pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PMIS-TS). In general, adolescents were more likely to be asymptomatic and less likely to develop fever, but required longer hospital stays. In conclusion, majority patients in this pediatric Asian cohort had a mild disease. None developed PIMS-TS. Their clinical characteristics were influenced by travel history and age.

引用

页码：2588 / 2596

页数：9

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