Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients

被引:11
作者
van der Torre, Mireille H. [1 ,2 ]
Shen, Hongwei [2 ]
Rautemaa-Richardson, Riina [1 ,2 ,3 ]
Richardson, Malcolm D. [1 ,2 ]
Novak-Frazer, Lilyann [1 ,2 ]
机构
[1] Manchester Univ NHS Fdn Trust, Wythenshawe Hosp, Mycol Reference Ctr Manchester, ECMM Ctr Excellence Clin & Lab Mycol & Clin Studi, Manchester M23 9LT, Lancs, England
[2] Univ Manchester, Fac Biol Med & Hlth, Div Infect Inflammat & Resp Med, Manchester M13 9PL, Lancs, England
[3] Manchester Univ NHS Fdn Trust, Wythenshawe Hosp, Dept Infect Dis, Manchester M23 9LT, Lancs, England
关键词
Aspergillus fumigatus; molecular epidemiology; chronic pulmonary aspergillosis; genotyping; genetic diversity; SINGLE NUCLEOTIDE POLYMORPHISMS; AZOLE RESISTANCE; TRIAZOLE-RESISTANCE; TYPING METHODS; NOSOCOMIAL ASPERGILLOSIS; INVASIVE ASPERGILLOSIS; TR34/L98H MUTATIONS; GENETIC DIVERSITY; CYSTIC-FIBROSIS; TANDEM REPEATS;
D O I
10.3390/jof7020152
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Molecular fungal genotyping techniques developed and employed for epidemiological studies have understandably concentrated on establishing the genetic diversity of Aspergillus fumigatus in invasive aspergillosis due to its severity, the urgency for treatment, and the need to demonstrate possible sources. Some early studies suggested that these strains were phenotypically, if not genotypically, different from others. However, with improved discrimination and evaluations, incorporating environmental as well as clinical isolates from other Aspergillus conditions (e.g., chronic pulmonary aspergillosis and cystic fibrosis), this premise is no longer upheld. Moreover, with the onset of increased global triazole resistance, there has been a concerted effort to incorporate resistance profiling into genotyping studies and the realisation that the wider population of non-immunocompromised aspergillosis patients are at risk. This review summarises the developments in molecular genotyping studies that incorporate resistance profiling with attention to chronic pulmonary aspergillosis and an example of our UK experience.
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页码:1 / 20
页数:19
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