Amino acid capture and utilization within the Mycobacterium tuberculosis phagosome

被引：19
作者：
Gouzy, Alexandre [1 ,2 ]
Poquet, Yannick [1 ,2 ]
Neyrolles, Olivier [1 ,2 ]
机构：
[1] CNRS, IPBS, UMR 5089, F-31077 Toulouse 04, France
[2] Univ Toulouse 3, Univ Toulouse, IPBS, F-31077 Toulouse, France
来源：
FUTURE MICROBIOLOGY | 2014年 / 9卷 / 05期
关键词：
asparaginase; asparagine; aspartate; macrophage; Mycobacterium tuberculosis; permease; phagosome; ISOCITRATE LYASE-1; CARBON METABOLISM; UREASE ACTIVITY; REQUIRES; PERSISTENCE; TRANSPORTERS; MACROPHAGES; HOMEOSTASIS; CATABOLISM; EXPRESSION;
D O I：
10.2217/fmb.14.28
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Mycobacterium tuberculosis, the agent of TB, is a facultative intracellular bacterial pathogen that replicates inside host macrophages and other phagocytes within a membrane-bound vacuole or phagosome. How M. tuberculosis captures and exploits vital nutrients inside host cells is an intensive research area that might lead to novel therapeutics for tuberculosis. Recent reports provided evidence that M. tuberculosis relies on amino acid uptake and degradation pathways to thrive inside its host. This opens novel research venues for the development of innovative antimicrobials against TB.
引用
收藏
页码：631 / 637
页数：7
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