CD5 Negative, Cyclin D1-positive Diffuse Large B-cell Lymphoma (DLBCL) Presenting as Ruptured Spleen

被引：6
作者：
Teruya-Feldstein, Julie [1 ]
Gopalan, Anuradha
Moskowitz, Craig H. [2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, Immunohistochem Lab, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA
来源：
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2009年 / 17卷 / 03期
关键词：
CD5; negative; cyclin D1-positive DLBCL; pleomorphic mantle cell lymphoma; splenic rupture; PATHOLOGICAL SPLENIC RUPTURE; CHRONIC LYMPHOCYTIC-LEUKEMIA; STERNBERG-LIKE CELLS; AGGRESSIVE VARIANTS; BLASTOID VARIANT; HODGKINS-DISEASE; MANTLE; OVEREXPRESSION; EXPRESSION; MUTATIONS;
D O I：
10.1097/PAI.0b013e318182d2aa
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
We present a case of diffuse large B-cell lymphoma CD5 negative. Cyclin D I positive presenting as ruptured spleen in a 63-year-old man requiring emergent splenectomy. Tumor cells showed marked pleomorphism, anaplasia, and increased mitotic figures with positive Cyclin D1, BCL6, MUM1, P53, and a high MIB1 proliferative fraction. The patient received Multiple therapies and ultimately died. This case raises the differential diagnoses of pleomorphic mantle cell lymphoma and other aggressive lymphomas with pleomorphic, anaplastic, and Reed-Sternberg-like cells.
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收藏
页码：255 / 258
页数：4
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