Development and initial validation of a composite disease activity score for systemic juvenile idiopathic arthritis

被引:45
作者
Tibaldi, Jessica [1 ,2 ]
Pistorio, Angela [3 ]
Aldera, Elena [2 ]
Puzone, Laura [2 ]
El Miedany, Yasser [4 ]
Pal, Priyankar [5 ]
Giri, Prabhas Prasun [5 ]
De, Hriday [5 ]
Khubchandani, Raju [6 ]
Chavan, Pallavi Pimpale [6 ]
Vilaiyuk, Soamarat [7 ]
Lerkvaleekul, Butsabong [7 ]
Yamsuwan, Jutamas [7 ]
Sabui, Tapas K. [8 ]
Datta, Pragati [8 ]
Pardeo, Manuela [9 ]
Bracaglia, Claudia [9 ]
Sawhney, Sujata [10 ]
Mittal, Sumidha [10 ]
Hassan, Waleed A. [11 ]
Elderiny, Ghada Farouk [12 ]
Abu-Zaid, Mohammed Hassan [13 ]
Eissa, Mervat [14 ]
Sztajnbok, Flavio [15 ]
Sztajnbok, Fernanda C. das Neves [16 ]
Russo, Ricardo [17 ]
Katsicas, Maria Martha [17 ]
Cimaz, Rolando [18 ]
Marrani, Edoardo [19 ]
Alexeeva, Ekaterina [20 ,21 ]
Dvoryakovskaya, Tatyana M. [20 ,21 ]
Alsuweiti, Motasem O. [22 ]
Alzyoud, Ra'ed M. [22 ]
Kostik, Mikhail [23 ]
Chikova, Irina [23 ]
Minoia, Francesca [24 ]
Filocamo, Giovanni [24 ]
Farag, Yomna [14 ]
Lotfy, Hala [14 ]
Nasef, Samah Ismail [25 ]
Al-Mayouf, Sulaiman M. [26 ]
Maggio, Maria Cristina [27 ]
Magalhaes, Claudia Saad [28 ]
Gallizzi, Romina [29 ]
Conti, Giovanni [30 ]
Shimizu, Masaki [31 ]
Civino, Adele [32 ]
Felici, Enrico [33 ]
Giancane, Gabriella [1 ,2 ]
Ruperto, Nicolino [1 ]
机构
[1] IRCCS Ist Giannina Gaslini, UOC Clin Pediat & Reumatol, Genoa, Italy
[2] Univ Genoa, Dipartimento Neurosci Riabilitaz Oftalmol Genet &, Genoa, Italy
[3] IRCCS Ist Giannina Gaslini, Dipartimento Epidemiol & Biostat, Genoa, Italy
[4] Ain Shams Univ, Fac Med, Cairo, Egypt
[5] Inst Child Hlth, Pediat Rheumatol Div, Kolkata, India
[6] SRCC Childrens Hosp, Sect Pediat Rheumatol, Mumbai, Maharashtra, India
[7] Mahidol Univ, Fac Med Ramathibodi Hosp, Pediat Dept, Rheumatol Div, Bangkok, Thailand
[8] RG Kar Med Coll, Pediat Rheumatol Clin, Kolkata, India
[9] IRCCS Osped Pediat Bambino Gesu, Div Rheumatol, Rome, Italy
[10] Sir Ganga Ram Hosp, Inst Child Hlth, Div Pediat Rheumatol, New Delhi, India
[11] Benha Univ, Fac Med, Banha, Egypt
[12] Alexandria Univ, Fac Med, Alexandria, Egypt
[13] Tanta Univ, Fac Med, Tanta, Egypt
[14] Cairo Univ, Fac Med, Cairo, Egypt
[15] Univ Estado Rio de Janeiro, Pediat Rheumatol Div, Adolescent Hlth Care Unit, Rio De Janeiro, Brazil
[16] Univ Fed Rio de Janeiro, Dept Internal Med, Rio De Janeiro, Brazil
[17] Hosp Pediat Garrahan, Serv Inmunol & Reumatol, Buenos Aires, DF, Argentina
[18] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy
[19] Univ Hosp Meyer, Div Rheumatol, Florence, Italy
[20] Natl Med Res Ctr Childrens Hlth, Rheumatol Div, Moscow, Russia
[21] Sechenov First Moscow State Med Univ, Moscow, Russia
[22] Queen Rania Childrens Hosp, Dept Immunol Rheumatol & Allergy, Amman, Jordan
[23] St Petersburg State Pediat Med Univ, St Petersburg, Russia
[24] Fdn IRCCS Ca Granda Osped Maggiore Policlin, UOC Pediat Media Intensita Cure, Milan, Italy
[25] Suez Canal Univ, Fac Med, Rheumatol Dept, Ismailia, Egypt
[26] King Faisal Specialist Hosp & Res Ctr, Dept Pediat, Riyadh, Saudi Arabia
[27] Univ Palermo, Dipartimento Promise G DAlessandro, Palermo, Italy
[28] UNESP, Pediat Dept, Hosp Clin Botucatu Med Univ, Botucatu, SP, Brazil
[29] Azienda Osped Univ Gaetano Martino Messina, Serv Immunoreumatol Pediat, UOC Pediat, Messina, Italy
[30] Azienda Osped Univ Gaetano Martino, UO Nefrol & Reumatol Pediat, Messina, Italy
[31] Kanazawa Univ, Sch Med, Inst Med Pharmaceut & Hlth Sci, Dept Pediat, Kanazawa, Ishikawa, Japan
[32] Osped Vito Fazzi, Pediat Unit, Lecce, Italy
[33] AON SS Antonio & Biagio & Cesare Arrigo Childrens, Pediat Unit, Alessandria, Italy
关键词
systemic juvenile idiopathic arthritis; Still's disease; composite disease activity score; outcome measures; disease activity; clinical assessment; pediatric rheumatology; ACCEPTABLE SYMPTOM STATE; ONSET STILLS-DISEASE; DEFINING CRITERIA; SELECT CATEGORIES; COEFFICIENT; TOCILIZUMAB; REMISSION; CHILDREN; VALIDITY; TRIAL;
D O I
10.1093/rheumatology/keaa240
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To develop a composite disease activity score for systemic JIA (sJIA) and to provide preliminary evidence of its validity. Methods. The systemic Juvenile Arthritis Disease Activity Score (sJADAS) was constructed by adding to the four items of the original JADAS a fifth item that aimed to quantify the activity of systemic features. Validation analyses were conducted on patients with definite or probable/possible sJIA enrolled at first visit or at the time of a flare, who had active systemic manifestations, which should include fever. Patients were reassessed 2 weeks to 3 months after baseline. Three versions were examined, including ESR, CRP or no acute-phase reactant. Results. A total of 163 patients were included at 30 centres in 10 countries. The sJADAS was found to be feasible and to possess face and content validity, good construct validity, satisfactory internal consistency (Cronbach's alpha 0.64-0.65), fair ability to discriminate between patients with different disease activity states and between those whose parents were satisfied or not satisfied with illness outcome (P < 0.0001 for both), and strong responsiveness to change over time (standardized response mean 2.04-2.58). Overall, these properties were found to be better than those of the original JADAS and of DAS for RA and of Puchot score for adult-onset Still's disease. Conclusion. The sJADAS showed good measurement properties and is therefore a valid instrument for the assessment of disease activity in children with sJIA. The performance of the new tool should be further examined in other patient cohorts that are evaluated prospectively.
引用
收藏
页码:3505 / 3514
页数:10
相关论文
共 45 条
  • [1] Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score
    Aletaha, D
    Nell, VP
    Stamm, T
    Uffmann, M
    Pflugbeil, S
    Machold, K
    Smolen, JS
    [J]. ARTHRITIS RESEARCH & THERAPY, 2005, 7 (04) : R796 - R806
  • [2] Bellamy N, 1999, J RHEUMATOL, V26, P948
  • [3] Cross-cultural adaptation and psychometric evaluation of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR) in 54 languages across 52 countries: review of the general methodology
    Bovis, Francesca
    Consolaro, Alessandro
    Pistorio, Angela
    Garrone, Marco
    Scala, Silvia
    Patrone, Elisa
    Rinaldi, Mariangela
    Villa, Luca
    Martini, Alberto
    Ravelli, Angelo
    Ruperto, Nicolino
    [J]. RHEUMATOLOGY INTERNATIONAL, 2018, 38 : 5 - 17
  • [4] Developing outcome measures for paediatric rheumatic diseases
    Brunner, Hermine I.
    Ravelli, Angelo
    [J]. BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2009, 23 (05): : 609 - 624
  • [5] A COEFFICIENT OF AGREEMENT FOR NOMINAL SCALES
    COHEN, J
    [J]. EDUCATIONAL AND PSYCHOLOGICAL MEASUREMENT, 1960, 20 (01) : 37 - 46
  • [6] Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study
    Consolaro, Alessandro
    Giancane, Gabriella
    Alongi, Alessandra
    van Dijkhuizen, Evert Hendrik Pieter
    Aggarwal, Amita
    Al-Mayouf, Sulaiman M.
    Bovis, Francesca
    De Inocencio, Jaime
    Demirkaya, Erkan
    Flato, Berit
    Foell, Dirk
    Garay, Stella Maris
    Lazar, Calin
    Lovell, Daniel J.
    Montobbio, Carolina
    Miettunen, Paivi
    Mihaylova, Dimitrina
    Nielsen, Susan
    Orban, Ilonka
    Rumba-Rozenfelde, Ingrida
    Magalhaes, Claudia Saad
    Shafaie, Nahid
    Susic, Gordana
    Trachana, Maria
    Wulffraat, Nico
    Pistorio, Angela
    Martini, Alberto
    Ruperto, Nicolino
    Ravelli, Prof Angelo
    Abdwani, Reem
    Aghighi, Yahya
    Aiche, Maya-Feriel
    Ailioaie, Constantin
    Ayaz, Nuray Aktay
    Al-Abrawi, Safiya
    Alexeeva, Ekaterina
    Anton, Jordi
    Apostol, Adriana
    Arguedas, Olga
    Avcin, Tadej
    Barone, Patrizia
    Berntson, Lillemor
    Lucica Boteanu, Alina
    Boyko, Yaryna
    Burgos-Vargas, Ruben
    Calvo Penades, Inmaculada
    Chedeville, Gaelle
    Cimaz, Rolando
    Civino, Adele
    Consolini, Rita
    [J]. LANCET CHILD & ADOLESCENT HEALTH, 2019, 3 (04) : 255 - 263
  • [7] Unraveling the Phenotypic Variability of Juvenile Idiopathic Arthritis across Races or Geographic Areas - Key to Understanding Etiology and Genetic Factors?
    Consolaro, Alessandro
    Ravelli, Angelo
    [J]. JOURNAL OF RHEUMATOLOGY, 2016, 43 (04) : 683 - 685
  • [8] Defining Criteria for Disease Activity States in Nonsystemic Juvenile Idiopathic Arthritis Based on a Three-Variable Juvenile Arthritis Disease Activity Score
    Consolaro, Alessandro
    Negro, Giorgia
    Gallo, Maria Chiara
    Bracciolini, Giulia
    Ferrari, Cristina
    Schiappapietra, Benedetta
    Pistorio, Angela
    Bovis, Francesca
    Ruperto, Nicolino
    Martini, Alberto
    Ravelli, Angelo
    [J]. ARTHRITIS CARE & RESEARCH, 2014, 66 (11) : 1703 - 1709
  • [9] Defining criteria for high disease activity in juvenile idiopathic arthritis based on the Juvenile Arthritis Disease Activity Score
    Consolaro, Alessandro
    Ruperto, Nicolino
    Bracciolini, Giulia
    Frisina, Alessia
    Gallo, Maria Chiara
    Pistorio, Angela
    Verazza, Sara
    Negro, Giorgia
    Gerloni, Valeria
    Goldenstein-Schainberg, Claudia
    Sztajnbok, Flavio
    Wulffraat, Nico M.
    Martini, Alberto
    Ravelli, Angelo
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (07) : 1380 - 1383
  • [10] Remission, minimal disease activity, and acceptable symptom state in juvenile idiopathic arthritis: Defining criteria based on the juvenile arthritis disease activity score
    Consolaro, Alessandro
    Bracciolini, Giulia
    Ruperto, Nicolino
    Pistorio, Angela
    Magni-Manzoni, Silvia
    Malattia, Clara
    Pederzoli, Silvia
    Davi, Sergio
    Martini, Alberto
    Ravelli, Angelo
    [J]. ARTHRITIS AND RHEUMATISM, 2012, 64 (07): : 2366 - 2374