A concise enantioselective pathway to carbocyclic nucleoside: Asymmetric synthesis of carbocyclic moiety of carbovir

被引：13

作者：

Tanimori, S

Tsubota, M

He, MQ

Nakayama, M

机构：

[1] Department of Applied Biochemistry, College of Agriculture, Osaka Prefecture University, Sakai, Osaka 593

来源：

SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 14期

关键词：

D O I：

10.1080/00397919708004098

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(-)-Trans-4-t-butyldimethylsilyloxymethyl-2-cyclopentenol (13), a key intermediate for the synthesis of (-)-carbovir (15), was synthesized by using enantioselective bicyclic ring construction of chiral alpha-diazo-beta-keto ester 3 catalyzed by rhodium (II) acetate.

引用

页码：2371 / 2378

页数：8

共 13 条

[11] SYNTHESIS AND ANTI-HIV ACTIVITY OF CARBOCYCLIC 2',3'-DIDEHYDRO-2',3'-DIDEOXY 2,6-DISUBSTITUTED PURINE NUCLEOSIDES [J].