Immune-mediated enteropathies: From bench to bedside

被引：14

作者：

van Wanrooij, Roy L. J. ^{[1
]}

Bontkes, Hetty J. ^{[2
]}

Neefjes-Borst, E. Andra ^{[3
]}

Mulder, Chris J. ^{[1
]}

Bouma, Gerd ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Amsterdam UMC, Dept Gastroenterol & Hepatol, AGEM Res Inst, Amsterdam, Netherlands

[2] Amsterdam UMC, AGEM Res Inst, Dept Clin Chem, Lab Med Immunol,AI & I Inst, Amsterdam, Netherlands

[3] Amsterdam UMC, Dept Pathol, Amsterdam, Netherlands

来源：

JOURNAL OF AUTOIMMUNITY | 2021年 / 118卷

关键词：

Immune-mediated enteropathy; Celiac disease; Refractory celiac disease; Olmesartan-associated enteropathy; Autoimmune enteropathy; Indolent T-cell lymphoma; Eosinophilic enteritis; Graft-versus-host disease; Common variable immunodeficiency syndrome; REFRACTORY CELIAC-DISEASE; T-CELL LYMPHOMA; COMMON VARIABLE IMMUNODEFICIENCY; GLUTEN-FREE DIET; VERSUS-HOST-DISEASE; INTESTINAL INTRAEPITHELIAL LYMPHOCYTES; SPRUE-LIKE ENTEROPATHY; AUTOIMMUNE ENTEROPATHY; VILLOUS ATROPHY; EOSINOPHILIC GASTROENTERITIS;

D O I：

10.1016/j.jaut.2021.102609

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune-mediated enteropathies are caused by excessive reactions of the intestinal immune system towards nonpathogenic molecules. Enteropathy leads to malabsorption-related symptoms and include (severe) chronic diarrhea, weight loss and vitamin deficiencies. Parenteral feeding and immunosuppressive therapy are needed in severe cases. Celiac disease has long been recognized as the most common immune-mediated enteropathy in adults, but the spectrum of immune-mediated enteropathies has been expanding. Histological and clinical features are sometimes shared among these enteropathies, and therefore it may be challenging to differentiate between them. Here, we provide an overview of immune-mediated enteropathies focused on clinical presentation, establishing diagnosis, immunopathogenesis, and treatment options.

引用

页数：12

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