Hyperglycaemia in acute ischaemic stroke is associated with an increased 5-year mortality

被引:22
作者
Kostulas, Nikolaos [1 ]
Markaki, Ioanna [1 ]
Cansu, Helen [1 ]
Masterman, Thomas [1 ]
Kostulas, Vasilios [1 ]
机构
[1] Karolinska Univ Hosp, Karolinska Inst, Dept Neurol, Neuroangiol Res Ctr, Huddinge, Sweden
关键词
hyperglycemia; ischemic stroke; long-term mortality; elderly; ADMISSION HYPERGLYCEMIA; BLOOD-GLUCOSE; ATTACK; TRIAL; PREVALENCE; INSULIN; RISK;
D O I
10.1093/ageing/afp120
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective: to evaluate the influence of admission HG [blood glucose (BG) levels > 8 mmol/L] on long-term mortality after ischaemic stroke (IS) and transient ischaemic attack (TIA). Methods: consecutive patients with IS or TIA, admitted from January 1997 until December 2002, were retrospectively screened. BG was measured within 3 days from onset of symptoms. Information on the date of death was obtained within 10 years after onset. Results: a total of 509 patients (78% IS; 22% TIA) were included. Admission HG was present in 28% and 18% of the IS and TIA patients, respectively (P = 0.05). Mean admission BG was 7.6 +/- 3.2 mmol/L in the IS and 6.7 +/- 2.3 mmol/L in TIA (P = 0.002). During a mean observation of 66 +/- 35 months, the overall 1- and 10-year mortality rate was 12% and 51% in IS compared to 4% and 38% in TIA patients (P = 0.004). Normoglycaemic IS patients had a longer median survival than those with HG (113 vs 84 months, P = 0.04). Admission HG did not affect the mortality rates in TIA patients. Conclusion: admission HG is associated with greater mortality rates up to 5 years after stroke but does not influence the survival of TIA patients.
引用
收藏
页码:590 / 594
页数:5
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