Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation and Damage In Exhaustive Exercise

被引:31
作者
Beck, Wladimir Rafael [1 ]
Botezelli, Jose Diego [2 ]
Pauli, Jose Rodrigo [2 ]
Ropelle, Eduardo Rochete [2 ]
Gobatto, Claudio Alexandre [1 ]
机构
[1] Univ Estadual Campinas, Lab Appl Sport Physiol, Sch Appl Sci, Dept Sport Sci, BR-13484350 Sao Paulo, Brazil
[2] Univ Estadual Campinas, Lab Mol Biol Exercise, Sch Appl Sci, Dept Sport Sci, BR-13484350 Sao Paulo, Brazil
来源
SCIENTIFIC REPORTS | 2015年 / 5卷
基金
巴西圣保罗研究基金会;
关键词
NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; INDUCIBLE ISOFORM; OXIDATIVE STRESS; PERFORMANCE; MUSCLE; EXPRESSION; RESPONSES; RATS; METABOLISM;
D O I
10.1038/srep18065
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
It is well documented that exhaustive physical exercise leads to inflammation and skeletal muscle tissue damage. With this in mind, melatonin has been acutely administered before physical exercise; nevertheless, the use of melatonin as an ergogenic agent to prevent tissue inflammation and damage remains uncertain. We evaluated the effects of melatonin on swimming performance, muscle inflammation and damage and several physiological parameters after exhaustive exercise at anaerobic threshold intensity (iLAn) performed during light or dark circadian periods. The iLAn was individually determined and two days later, the animals performed an exhaustive exercise bout at iLAn 30 minutes after melatonin administration. The exercise promoted muscle inflammation and damage, mainly during the dark period, and the exogenous melatonin promoted a high ergogenic effect. The expressive ergogenic effect of melatonin leads to longer periods of muscle contraction, which superimposes a possible melatonin protective effect on the tissue damage and inflammation.
引用
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页数:10
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