Successful Hematopoietic Reconstitution by Unrelated Donor Cord Blood Transplantation in Children With Fanconi Anemia: Report of 3 Cases

被引：3

作者：

Jaing, Tang-Her ^{[1
]}

Chen, Shih-Hsiang ^{[1
]}

Yang, Chao-Ping ^{[1
]}

Hung, Iou-Jih ^{[1
]}

Chang, Tsung-Yen ^{[1
]}

Hsueh, Chuen ^{[2
]}

机构：

[1] Chang Gung Univ, Chang Gung Childrens Hosp, Div Hematol Oncol, Dept Pediat, Taoyuan 33305, Taiwan

[2] Chang Gung Univ, Chang Gung Mem Hosp, Dept Pathol, Taoyuan 33305, Taiwan

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2014年 / 36卷 / 08期

关键词：

Fanconi anemia; unrelated donor cord blood transplantation; donor chimerism; STEM-CELL TRANSPLANTATION; MARROW TRANSPLANTATION; ALTERNATIVE DONORS; EXPERIENCE; REGISTRY; DIAGNOSIS; REGIMEN;

D O I：

10.1097/MPH.0000000000000215

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To potentially reduce late effects of malignancy and chronic graft-versus-host disease in patients with Fanconi anemia, 3 patients received unmanipulated umbilical cord blood grafts with 0 or 1 HLA antigen mismatch. The conditioning regimen consisted of fludarabine (30 mg/m(2)/d) for 6 days, cyclophosphamide (60 mg/kg/d) for 2 days, and rabbit antithymocyte globulin (ATG) (2.5 mg/kg/d) for 3 days. Radiation was not used in the preparative regimen. None of the patients had significant conditioning-related toxicity. All were engrafted within 10 to 19 days. All patients are well with stable or full donor chimerism after a median follow-up of 64 months (range, 13 to 69 mo).

引用

页码：E553 / E555

页数：3

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