The Soy Isoflavone Genistein Regulates Estrogen Receptors in Several Tissues of Reporter Mice

被引：0

作者：

Montani, C. ^{[1
]}

Penza, M. ^{[1
]}

Jeremic, M. ^{[1
]}

Ciana, P. ^{[2
]}

Maggi, A. ^{[2
]}

Di Lorenzo, D. ^{[1
]}

机构：

[1] Civ Hosp Brescia, Lab Biotechnol 3, I-25123 Brescia, Italy

[2] Univ Milan, Ctr Excellence Neurodegenerat Dis, I-20133 Milan, Italy

来源：

PROCEEDINGS OF THE 13TH INTERNATIONAL CONGRESS OF ENDOCRINOLOGY | 2008年

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中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The isoflavone genistein is the most estrogenically active molecule present in soy. Here we show, by luciferase bioassays, that genistein induces ERs activation in reproductive and non-reproductive organs of the transgenic estrogen-reporter ERE-tK-LUC mice. Peak activity was registered at the genistein doses of 500-5000 mu g/kg at 12 hours. Our results show that genistein is estrogenic in reproductive anti non-reproductive organs of male mice in a close and time-dependent manner.

引用

页码：407 / +

页数：2

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