Serum Calcium Predicts Cognitive Decline and Clinical Progression of Alzheimer's Disease

被引：16
作者：
Ma, Ling-Zhi [1 ]
Wang, Zi-Xuan [2 ]
Wang, Zuo-Teng [1 ]
Hou, Xiao-He [1 ]
Shen, Xue-Ning [3 ,4 ]
Ou, Ya-Nan [1 ]
Dong, Qiang [3 ,4 ]
Tan, Lan [1 ]
Yu, Jin-Tai [3 ,4 ]
机构：
[1] Qingdao Univ, Qingdao Municipal Hosp, Dept Neurol, Qingdao, Peoples R China
[2] Qingdao Univ, Dept Geriatr Med, Affiliated Hosp, Qingdao, Peoples R China
[3] Fudan Univ, Shanghai Med Coll, Huashan Hosp, Dept Neurol, Shanghai, Peoples R China
[4] Fudan Univ, Shanghai Med Coll, Huashan Hosp, Inst Neurol, Shanghai, Peoples R China
来源：
NEUROTOXICITY RESEARCH | 2021年 / 39卷 / 03期
基金：
国家重点研发计划; 美国国家卫生研究院; 中国国家自然科学基金; 加拿大健康研究院;
关键词：
Calcium; Alzheimer’ s disease; Aβ (42); FDG-PET; Brain volume; COMPOSITE SCORE; DEMENTIA; ASSOCIATION; DIAGNOSIS; PEOPLE;
D O I：
10.1007/s12640-020-00312-y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Relationship between serum calcium and Alzheimer's disease (AD) remains unclear. The aim of this study is to test whether serum calcium is associated with other AD-associated biomarkers and could predict clinical progression in nondemented elders. This was a longitudinal population-based study. The sample was derived from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort, which included 1224 nondemented elders: 413 cognitively normal (CN) and 811 mild cognition impairment (MCI). Associations were investigated between serum calcium and longitudinal changes in A beta/tau pathologic features, brain structure, cognitive function, and disease progression. Serum calcium concentrations increased with disease severity. Serum calcium predicted longitudinal cognitive decline and conversion from nondemented status to AD dementia (adjusted HR = 1.41, 95% CI 1.13-1.76). Furthermore, serum calcium levels were negatively correlated with CSF-A beta(42) (beta = - 0.558, P = 0.008), FDG-PET (beta = - 0.292, P < 0.001), whole brain volume (beta = - 0.148, P = 0.001), and middle temporal volume (beta = - 0.216, P = 0.042). Similar results were obtained in CN and MCI groups. Higher serum calcium status (even if not hypercalcemia) may increase the risk of AD in elders. Serum calcium is a useful biomarker in predicting clinical progression in nondemented elders. More researches are needed in the future to explore the underlying mechanism.
引用
收藏
页码：609 / 617
页数：9
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