Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway

被引:32
作者
Chen, Jing [1 ,2 ]
Chen, Yuping [2 ,3 ]
Shu, Anmei [2 ]
Lu, Jinfu [2 ]
Du, Qiu [2 ]
Yang, Yuwei [1 ]
Lv, Zhiyang [1 ,2 ]
Xu, Huiqin [2 ]
机构
[1] Nanjing Univ Chinese Med, Hanlin Coll, Taizhou 225300, Peoples R China
[2] Nanjing Univ Chinese Med, Coll Pharm, Dept Pharmacol, Nanjing 210023, Jiangsu, Peoples R China
[3] Jiangsu Vocat Coll Med, Dept Basic Med Sci, Yancheng, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
TRADITIONAL CHINESE MEDICINE; GENE ONTOLOGY; STREPTOZOTOCIN; PHARMACOLOGY; COMBINATION; CYTOSCAPE; CATALPOL; LOGANIN; SYSTEM;
D O I
10.1155/2020/8358102
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Aims. Radix Rehmanniae and Corni Fructus (RC) have been widely applied to treat diabetic nephropathy (DN) for centuries. But the mechanism of how RC plays the therapeutic role against DN is unclear as yet. Methods. The information about RC was obtained from a public database. The active compounds of RC were screened by oral bioavailability (OB) and drug-likeness (DL). Gene ontology (GO) analysis was performed to realize the key targets of RC, and an active compound-potential target network was created. The therapeutic effects of RC active compounds and their key signal pathways were preliminarily probed via network pharmacology analysis and animal experiments. Results. In this study, 29 active compounds from RC and 64 key targets related to DN were collected using the network pharmacology method. The pathway enrichment analysis showed that RC regulated advanced glycosylation end product (AGE-) RAGE and IL-17 signaling pathways to treat DN. The animal experiments revealed that RC significantly improved metabolic parameters, inflammation renal structure, and function to protect the kidney against DN. Conclusions. The results revealed the relationship between multicomponents and multitargets of RC. The administratiom of RC might remit the DM-induced renal damage through the AGE-RAGE signaling pathway to improve metabolic parameters and protect renal structure and function.
引用
收藏
页数:15
相关论文
共 44 条
[1]   Gene Ontology: tool for the unification of biology [J].
Ashburner, M ;
Ball, CA ;
Blake, JA ;
Botstein, D ;
Butler, H ;
Cherry, JM ;
Davis, AP ;
Dolinski, K ;
Dwight, SS ;
Eppig, JT ;
Harris, MA ;
Hill, DP ;
Issel-Tarver, L ;
Kasarskis, A ;
Lewis, S ;
Matese, JC ;
Richardson, JE ;
Ringwald, M ;
Rubin, GM ;
Sherlock, G .
NATURE GENETICS, 2000, 25 (01) :25-29
[2]   ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks [J].
Bindea, Gabriela ;
Mlecnik, Bernhard ;
Hackl, Hubert ;
Charoentong, Pornpimol ;
Tosolini, Marie ;
Kirilovsky, Amos ;
Fridman, Wolf-Herman ;
Pages, Franck ;
Trajanoski, Zlatko ;
Galon, Jerome .
BIOINFORMATICS, 2009, 25 (08) :1091-1093
[3]   Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells [J].
Choi, Hee-Jung ;
Jang, Hye-Jin ;
Chung, Tae-Wook ;
Jeong, Seung-Il ;
Cha, Jaeho ;
Choi, Jun-Young ;
Han, Chang Woo ;
Jang, Yong-Suk ;
Joo, Myungsoo ;
Jeong, Han-Sol ;
Ha, Ki-Tae .
FITOTERAPIA, 2013, 86 :19-28
[4]   Effect of catalpol on diabetic nephropathy in rats [J].
Dong, Zhao ;
Chen, Chang Xun .
PHYTOMEDICINE, 2013, 20 (11) :1023-1029
[5]   Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis [J].
Feng, Simin ;
Gan, Ling ;
Yang, Chung S. ;
Liu, Anna B. ;
Lu, Wenyun ;
Shao, Ping ;
Dai, Zhuqing ;
Sun, Peilong ;
Luo, Zisheng .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, 66 (13) :3417-3425
[6]   Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin-to-creatinine ratio [J].
Galvao Ururahy, Marcela Abbott ;
Costa de Souza, Karla Simone ;
da Costa Oliveira, Yonara Monique ;
Loureiro, Melina Bezerra ;
Vital da Silva, Heglayne Pereira ;
Freire-Neto, Francisco Paulo ;
Bezerra, Joao Felipe ;
Luchessi, Andre Ducati ;
Doi, Sonia Quateli ;
Crespo Hirata, Rosario Dominguez ;
Almeida, Maria das Gracas ;
Arrais, Ricardo Fernando ;
Hirata, Mario Hiroyuki ;
de Rezende, Adriana Augusto .
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2015, 31 (05) :500-506
[7]   Effective blockade of RAAS by combination of aliskiren and olmesartan improves glucose homeostasis, glomerular filtration rate along with renal variables in streptozotocin induced diabetic rats [J].
Gandhi, Sonia ;
Srinivasan, B. P. ;
Akarte, Atul Sureshrao .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 46 (1-2) :32-42
[8]  
Hamosh A, 2005, NUCLEIC ACIDS RES, V33, pD514
[9]   Network pharmacology: the next paradigm in drug discovery [J].
Hopkins, Andrew L. .
NATURE CHEMICAL BIOLOGY, 2008, 4 (11) :682-690
[10]   Network pharmacology [J].
Hopkins, Andrew L. .
NATURE BIOTECHNOLOGY, 2007, 25 (10) :1110-1111