Effects of ursodeoxycholate and its conjugates on biliary glutathione excretion in rats

被引：7
作者：
Takikawa, H
Sano, N
Yamanaka, M
机构：
[1] Department of Medicine, Teikyo University, School of Medicine, Tokyo
[2] Department of Medicine, Teikyo University, School of Medicine, Itahashi-ku, Tokyo 173
来源：
DIGESTIVE DISEASES AND SCIENCES | 1996年 / 41卷 / 10期
关键词：
bile acid; ursodeoxycholate; glucuronide; sulfate; glutathione; biliary excretion;
D O I：
10.1007/BF02093595
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The effects of ursodeoxycholate and its conjugates on biliary glutathione excretion were studied in rats. Ursodeoxycholate had no effect on glutathione excretion, but tauroursodeoxycholate (10 mu mol/100 g body wt) transitionally increased biliary glutathione excretion. Ursodeoxycholate-3-O-glucuronide (2 and 10 mu mol/100 g body wt) markedly inhibited biliary glutathione excretion, but ursodeoxycholate-3-sulfate (2 mu mol/100 g body wt) and ursodeoxycholate-3,7-disulfate (10 mu mol/100 g body wt) did not. These findings indicate the existence of several biliary excretion pathways for bile acid glucuronides and sulfates and that one of them for the glucuronides is shared by biliary glutathione excretion.
引用
收藏
页码：1953 / 1958
页数：6
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