Novel alginate-acrylic polymers as a platform for drug delivery

被引：21
作者：
Laurienzo, Paola
Malinconico, Mario
Mattia, Giuditta
Russo, Roberto
La Rotonda, M. I.
Quaglia, Fabiana
Capitani, Donatella
Mannina, Luisa
机构：
[1] CNR, Ist Chim & Tecnol Polimerici, I-80078 Naples, Italy
[2] Univ Naples Federico II, Dipartimento Chim Farmaceut & Tossicol, I-80138 Naples, Italy
[3] CNR, Ist Metodol Chim, Area Ric Roma, I-00016 Rome, Italy
[4] Univ Molise, Dipartimento STAAM, I-86100 Campobasso, Italy
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2006年 / 78A卷 / 03期
关键词：
acrylics; alginate; bioadhesion; controlled drug release; diffusion-ordered NMR spectroscopy;
D O I：
10.1002/jbm.a.30763
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The aim of the present work was to develop a family of novel materials based on a combination of sodium alginate and acrylic polymers and to evaluate their potential in drug delivery applications. In the presence of sodium alginate, acrylic chains with acidic as well as basic moieties were polymerized to create an interpolymer complex based on electrostatic interactions that are able to modulate the release rate of low molecular weight drugs. The synthesized materials were used to prepare hydrophilic matrices for drug delivery and tested for their adhesion properties to glass, used as a model substrate for mucoadhesion. (c) 2006 Wiley Periodicals, Inc.
引用
收藏
页码：523 / 531
页数：9
相关论文
共 31 条
[1]   A novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of chitosan [J].
Ahn, JS ;
Choi, HK ;
Cho, CS .
BIOMATERIALS, 2001, 22 (09) :923-928
[2]  
Chandy T, 1998, J APPL POLYM SCI, V70, P2143, DOI 10.1002/(SICI)1097-4628(19981212)70:11<2143::AID-APP7>3.0.CO
[3]  
2-L
[4]   Mucoadhesive drug carrier based on interpolymer complex of poly(vinyl pyrrolidone) and poly(acrylic acid) prepared by template polymerization [J].
Chun, MK ;
Cho, CS ;
Choi, HK .
JOURNAL OF CONTROLLED RELEASE, 2002, 81 (03) :327-334
[5]   Synthesis and partial characterization of hydrogels obtained via glutaraldehyde crosslinking of acetylated chitosan and of hyaluronan derivatives [J].
Crescenzi, V ;
Francescangeli, A ;
Taglienti, A ;
Capitani, D ;
Mannina, L .
BIOMACROMOLECULES, 2003, 4 (04) :1045-1054
[6]  
El-Kamel A, 2002, AAPS PHARMSCI, V4
[7]   In-vitro comparative study of buccal mucoadhesive performance of different polymeric films [J].
Eouani, C ;
Piccerelle, P ;
Prinderre, P ;
Bourret, E ;
Joachim, J .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2001, 52 (01) :45-55
[8]   Mucoadhesive vaginal tablets as veterinary delivery system for the controlled release of an antimicrobial drug, acriflavine [J].
Elisabetta Gavini ;
Vanna Sanna ;
Claudia Juliano ;
Maria Cristina Bonferoni ;
Paolo Giunchedi .
AAPS PharmSciTech, 3 (3)
[9]   SOLVENT SIGNAL SUPPRESSION IN NMR [J].
GUERON, M ;
PLATEAU, P ;
DECORPS, M .
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 1991, 23 :135-209
[10]   Sustained release of water-soluble drug from directly compressed alginate tablets [J].
Holte, O ;
Onsoyen, E ;
Myrvold, R ;
Karlsen, J .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 20 (4-5) :403-407
1234