Nicotinic acetylcholine receptors and the regulation of neuronal signalling

被引：496

作者：

Dajas-Bailador, F ^{[1
]}

Wonnacott, S ^{[1
]}

机构：

[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2004年 / 25卷 / 06期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.tips.2004.04.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neuronal nicotinic acetylcholine (nACh) receptors in the brain are more commonly associated with modulatory events than mediation of synaptic transmission. nACh receptors have a high permeability for Ca2+, and Ca2+ signals are pivotal in shaping nACh receptor-mediated neuromodulatory effects. In this review, we consider the mechanisms through which nACh receptors convert rapid ionic signals into sustained, wide-ranging phenomena. The complex Ca2+ responses that are generated after activation of nACh receptors can transmit information beyond the initial domain and facilitate the interface with many intracellular processes. These mechanisms underlie the diverse repertoire of neuronal activities of nicotine in the brain, from the enhancement of learning and memory, to addiction and neuroprotection.

引用

页码：317 / 324

页数：8

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