The effects of resveratrol administration on lipid oxidation in experimental renal ischemia-reperfusion injury in rats

被引：16
作者：
Baltaci, A. K. [1 ]
Gokbudak, H. [1 ]
Baltaci, S. B. [1 ]
Mogulkoc, R. [1 ]
Avunduk, M. C. [2 ]
机构：
[1] Selcuk Univ, Fac Med, Dept Physiol, TR-42031 Konya, Turkey
[2] Necmettin Erbakan Univ, Meram Fac Med, Dept Pathol, Konya, Turkey
来源：
BIOTECHNIC & HISTOCHEMISTRY | 2019年 / 94卷 / 08期
关键词：
Histopathology; lipid oxidation; rat; renal ischemia; reperfusion; resveratrol; STRESS;
D O I：
10.1080/10520295.2019.1612091
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We investigated how resveratrol affects lipid oxidation during experimental renal ischemia-reperfusion injury in rats. We used 48 adult male rats assigned to five groups: group 1, control; group 2, renal ischemia; group 3, renal ischemia + reperfusion; group 4, resveratrol + renal ischemia; group 5, resveratrol + renal ischemia + reperfusion. Plasma and renal tissue malondialdehyde (MDA), and erythrocyte and renal tissue glutathione (GSH) levels were measured and histologic changes in the renal tissue were examined. Ischemia-reperfusion affected the MDA-GSH balance adversely and caused histopathological changes in the renal tissue of the ischemia and ischemia + reperfusion groups. Resveratrol treatment normalized MDA and GSH levels as well as the histopathology that occurred in the renal tissue of the ischemia and ischemia + reperfusion groups.
引用
收藏
页码：592 / 599
页数：8
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  • [1] Chronic treatment with resveratrol improves overactive bladder in obese mice via antioxidant activity
    Alexandre, Eduardo C.
    Calmasini, Fabiano B.
    de Oliveira, Mariana G.
    Silva, Fabio H.
    da Silva, Carmem P. V.
    Andre, Diana M.
    Leonardo, Flavia C.
    Delbin, Maria A.
    Antunes, Edson
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2016, 788 : 29 - 36
  • [2] Prevention of renal damage by alpha tocopherol in ischemia and reperfusion models of rats
    Avunduk, MC
    Yurdakul, T
    Erdemli, E
    Yavuz, A
    [J]. UROLOGICAL RESEARCH, 2003, 31 (04): : 280 - 285
  • [3] Resveratrol attenuates 4-hydroxy-2-hexenal-induced oxidative stress in mouse cortical collecting duct cells
    Bae, Eun Hui
    Joo, Soo Yeon
    Ma, Seong Kwon
    Lee, JongUn
    Kim, Soo Wan
    [J]. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2016, 20 (03) : 229 - 236
  • [4] Resveratrol and exercise
    Baltaci, Saltuk Bugra
    Mogulkoc, Rasim
    Baltaci, Abdulkerim Kasim
    [J]. BIOMEDICAL REPORTS, 2016, 5 (05) : 525 - 530
  • [5] Protective effect of nitric oxide pathway in resveratrol renal ischemia-reperfusion injury in rats
    Chander, V
    Chopra, K
    [J]. ARCHIVES OF MEDICAL RESEARCH, 2006, 37 (01) : 19 - 26
  • [6] TISSUE SULFHYDRYL GROUPS
    ELLMAN, GL
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) : 70 - 77
  • [7] Insights into the properties of the two enantiomers of trans-δ-viniferin, a resveratrol derivative: antioxidant activity, biochemical and molecular modeling studies of its interactions with hemoglobin
    Ficarra, Silvana
    Tellone, Ester
    Pirolli, Davide
    Russo, Annamaria
    Barreca, Davide
    Galtieri, Antonio
    Giardina, Bruno
    Gavezzotti, Paolo
    Riva, Sergio
    De Rosa, Maria Cristina
    [J]. MOLECULAR BIOSYSTEMS, 2016, 12 (04) : 1276 - 1286
  • [8] Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys
    Giovannini, L
    Migliori, M
    Longoni, BM
    Das, DK
    Bertelli, AAE
    Panichi, SV
    Filippi, C
    Bertelli, A
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2001, 37 (03) : 262 - 270
  • [9] Novel resveratrol analogues attenuate renal ischemic injury in rats
    Khader, Adam
    Yang, Weng-Lang
    Kuncewitch, Michael
    Prince, Jose M.
    Marambaud, Philippe
    Nicastro, Jeffrey
    Coppa, Gene F.
    Wang, Ping
    [J]. JOURNAL OF SURGICAL RESEARCH, 2015, 193 (02) : 807 - 815
  • [10] Resveratrol Protects against Titanium Particle-Induced Aseptic Loosening Through Reduction of Oxidative Stress and Inactivation of NF-κB
    Luo, Guotian
    Li, Ziqing
    Wang, Yu
    Wang, Haixing
    Zhang, Ziji
    Chen, Weishen
    Zhang, Yangchun
    Xiao, Yinbo
    Li, Chaohong
    Guo, Ying
    Sheng, Puyi
    [J]. INFLAMMATION, 2016, 39 (02) : 775 - 785
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