The effects of resveratrol administration on lipid oxidation in experimental renal ischemia-reperfusion injury in rats

被引：17
作者：
Baltaci, A. K. [1 ]
Gokbudak, H. [1 ]
Baltaci, S. B. [1 ]
Mogulkoc, R. [1 ]
Avunduk, M. C. [2 ]
机构：
[1] Selcuk Univ, Fac Med, Dept Physiol, TR-42031 Konya, Turkey
[2] Necmettin Erbakan Univ, Meram Fac Med, Dept Pathol, Konya, Turkey
来源：
BIOTECHNIC & HISTOCHEMISTRY | 2019年 / 94卷 / 08期
关键词：
Histopathology; lipid oxidation; rat; renal ischemia; reperfusion; resveratrol; STRESS;
D O I：
10.1080/10520295.2019.1612091
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We investigated how resveratrol affects lipid oxidation during experimental renal ischemia-reperfusion injury in rats. We used 48 adult male rats assigned to five groups: group 1, control; group 2, renal ischemia; group 3, renal ischemia + reperfusion; group 4, resveratrol + renal ischemia; group 5, resveratrol + renal ischemia + reperfusion. Plasma and renal tissue malondialdehyde (MDA), and erythrocyte and renal tissue glutathione (GSH) levels were measured and histologic changes in the renal tissue were examined. Ischemia-reperfusion affected the MDA-GSH balance adversely and caused histopathological changes in the renal tissue of the ischemia and ischemia + reperfusion groups. Resveratrol treatment normalized MDA and GSH levels as well as the histopathology that occurred in the renal tissue of the ischemia and ischemia + reperfusion groups.
引用
收藏
页码：592 / 599
页数：8
相关论文
共 20 条
[1]   Chronic treatment with resveratrol improves overactive bladder in obese mice via antioxidant activity [J].
Alexandre, Eduardo C. ;
Calmasini, Fabiano B. ;
de Oliveira, Mariana G. ;
Silva, Fabio H. ;
da Silva, Carmem P. V. ;
Andre, Diana M. ;
Leonardo, Flavia C. ;
Delbin, Maria A. ;
Antunes, Edson .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2016, 788 :29-36
[2]   Prevention of renal damage by alpha tocopherol in ischemia and reperfusion models of rats [J].
Avunduk, MC ;
Yurdakul, T ;
Erdemli, E ;
Yavuz, A .
UROLOGICAL RESEARCH, 2003, 31 (04) :280-285
[3]   Resveratrol attenuates 4-hydroxy-2-hexenal-induced oxidative stress in mouse cortical collecting duct cells [J].
Bae, Eun Hui ;
Joo, Soo Yeon ;
Ma, Seong Kwon ;
Lee, JongUn ;
Kim, Soo Wan .
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2016, 20 (03) :229-236
[4]   Resveratrol and exercise [J].
Baltaci, Saltuk Bugra ;
Mogulkoc, Rasim ;
Baltaci, Abdulkerim Kasim .
BIOMEDICAL REPORTS, 2016, 5 (05) :525-530
[5]   Protective effect of nitric oxide pathway in resveratrol renal ischemia-reperfusion injury in rats [J].
Chander, V ;
Chopra, K .
ARCHIVES OF MEDICAL RESEARCH, 2006, 37 (01) :19-26
[6]   TISSUE SULFHYDRYL GROUPS [J].
ELLMAN, GL .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) :70-77
[7]   Insights into the properties of the two enantiomers of trans-δ-viniferin, a resveratrol derivative: antioxidant activity, biochemical and molecular modeling studies of its interactions with hemoglobin [J].
Ficarra, Silvana ;
Tellone, Ester ;
Pirolli, Davide ;
Russo, Annamaria ;
Barreca, Davide ;
Galtieri, Antonio ;
Giardina, Bruno ;
Gavezzotti, Paolo ;
Riva, Sergio ;
De Rosa, Maria Cristina .
MOLECULAR BIOSYSTEMS, 2016, 12 (04) :1276-1286
[8]   Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys [J].
Giovannini, L ;
Migliori, M ;
Longoni, BM ;
Das, DK ;
Bertelli, AAE ;
Panichi, SV ;
Filippi, C ;
Bertelli, A .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2001, 37 (03) :262-270
[9]   Novel resveratrol analogues attenuate renal ischemic injury in rats [J].
Khader, Adam ;
Yang, Weng-Lang ;
Kuncewitch, Michael ;
Prince, Jose M. ;
Marambaud, Philippe ;
Nicastro, Jeffrey ;
Coppa, Gene F. ;
Wang, Ping .
JOURNAL OF SURGICAL RESEARCH, 2015, 193 (02) :807-815
[10]   Resveratrol Protects against Titanium Particle-Induced Aseptic Loosening Through Reduction of Oxidative Stress and Inactivation of NF-κB [J].
Luo, Guotian ;
Li, Ziqing ;
Wang, Yu ;
Wang, Haixing ;
Zhang, Ziji ;
Chen, Weishen ;
Zhang, Yangchun ;
Xiao, Yinbo ;
Li, Chaohong ;
Guo, Ying ;
Sheng, Puyi .
INFLAMMATION, 2016, 39 (02) :775-785
12