Spirometric-gated computed tomography quantitative evaluation of lung emphysema in chronic obstructive pulmonary disease - A comparison of 3 techniques

被引:21
作者
Orlandi, I
Moroni, C
Camiciottoli, G
Bartolucci, M
Belli, G
Villari, N
Mascalchi, M
机构
[1] Univ Florence, Dipartimento Fisiopatol Clin, Sez Radiodiagnost, Florence, Italy
[2] Careggi Hosp, Dept Med Phys, Florence, Italy
[3] Univ Florence, Dept Crit Care, Resp Med Unit, Florence, Italy
关键词
high-resolution computed tomography; pulmonary emphysema; spirometric gating; spiral computed tomography; low dose;
D O I
10.1097/00004728-200407000-00001
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective: To compare the quantitative assessment of pulmonary emphysema with spirometric-gated computed tomography (gated CT) using 3 different acquisition techniques and to determine if low-current spiral CT could be used effectively to quantitate emphysema. Methods: Eleven patients with chronic obstructive pulmonary disease (COPD) underwent gated CT and pulmonary function tests (PFTs). Spiral whole-lung 10-mm collimation acquisitions at standard (146 mAs) and low (43 mAs) current and sequential 3-slice 1-mm collimation high-resolution computed tomography (HRCT) acquisitions at standard current were obtained at 90% of the patient's vital capacity. The mean lung density (MLD) and the pixel index (PI) derived from the 3 data sets were compared using one-way analysis of variance and correlated with PFTs using linear regression. Moreover, the radiation dose associated with each technique was measured. Results: The MLDs were not significantly different. The Pls calculated from the standard- and low-current spiral acquisitions were similar, and both were significantly different from that of HRCT. The MLDs correlated with the PFTs in standard-current spiral and HRCT but not in low-current spiral acquisitions, whereas the Pls correlated with the PFTs in all 3 techniques. High-resolution computed tomography implied the lowest dose (0.08 mSv) compared with low-current (1.2 mSv) and standard-current (4 mSv) spiral techniques. Conclusions: Low- and standard-dose spiral CT provides similar lung density data in COPD. The combination of low-dose whole-lung spiral CT and 3-slice HRCT represents the best compromise between the amount of information provided and radiation exposure to the patient and could be substituted for standard-dose spiral CT for quantitative evaluation of COPD.
引用
收藏
页码:437 / 442
页数:6
相关论文
共 27 条
[1]   LUNG-FUNCTION TESTING - SELECTION OF REFERENCE VALUES AND INTERPRETATIVE STRATEGIES [J].
不详 .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (05) :1202-1218
[2]  
Austin JHM, 1999, RADIOLOGY, V212, P1
[3]   Pulmonary emphysema: Subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry [J].
Bankier, AA ;
De Maertelaer, V ;
Keyzer, C ;
Gevenois, PA .
RADIOLOGY, 1999, 211 (03) :851-858
[4]  
Cederlund K, 2002, ACTA RADIOL, V43, P48
[5]  
CELLI BR, 1995, AM J RESP CRIT CARE, V152, pS77
[6]   A quantification of the lung surface area in emphysema using computed tomography [J].
Coxson, HO ;
Rogers, RM ;
Whittall, KP ;
D'Yachkova, Y ;
Paré, PD ;
Sciurba, FC ;
Hogg, JC .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (03) :851-856
[7]   Comparison of computed density and microscopic morphometry in pulmonary emphysema [J].
Gevenois, PA ;
DeVuyst, P ;
deMaertelaer, V ;
Zanen, J ;
Jacobvitz, D ;
Cosio, MG ;
Yernault, JC .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 154 (01) :187-192
[8]   Pulmonary emphysema: Quantitative CT during expiration [J].
Gevenois, PA ;
DeVuyst, P ;
Sy, M ;
Scillia, P ;
Chaminade, L ;
deMaertelaer, V ;
Zanen, J ;
Yernault, JC .
RADIOLOGY, 1996, 199 (03) :825-829
[9]   COMPARISON OF COMPUTED DENSITY AND MACROSCOPIC MORPHOMETRY IN PULMONARY-EMPHYSEMA [J].
GEVENOIS, PA ;
DEMAERTELAER, V ;
DEVUYST, P ;
ZANEN, J ;
YERNAULT, JC .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 152 (02) :653-657
[10]   MEASUREMENT OF PULMONARY PARENCHYMAL ATTENUATION - USE OF SPIROMETRIC GATING WITH QUANTITATIVE CT [J].
KALENDER, WA ;
RIENMULLER, R ;
SEISSLER, W ;
BEHR, J ;
WELKE, M ;
FICHTE, H .
RADIOLOGY, 1990, 175 (01) :265-268