Retinoic acid signaling at sites of plasticity in the nervous mature central system

被引:51
作者
Haskell, GT
Maynard, TM
Shatzmiller, RA
Lamantia, AS
机构
[1] Univ N Carolina, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Sch Med, Ctr Neurosci, Chapel Hill, NC 27599 USA
关键词
retinoic acid; plasticity; olfactory bulb; spinal cord; interneuron; cortex; amygdala; nabenula;
D O I
10.1002/cne.10369
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We used transgenic reporter mice to determine whether brain regions that respond to retinoic acid (RA) during development do so in maturity. We focused on two prominent sites of embryonic RA signaling: the dorsal spinal cord and the olfactory bulb. In the mature dorsal spinal cord, expression of a direct repeat 5 RA response element (DR5-RARE) transgene is seen in interneurons in laminae I and II, as well as in ependymal cells around the central canal. In the olfactory bulb, DR5-RARE transgene-expressing neurons are seen in the mature granule cell and periglomerular layers, as well as in cells in the subventricular zone of the forebrain-the established source for newly generated granule and periglomerular neurons. In addition, there are transgene-labeled neurons in a small number of other brain regions. These include the spinal trigeminal nucleus, area postrema, habenula, amygdala, and the cerebral cortex. Thus, a distinct type of RA-mediated gene expression, detected with the DR5-RARE reporter transgene, defines neurons, subependymal, or ependymal cells in discrete locations throughout the neuraxis. Some of these cells-particularly those in the spinal cord and olfactory bulb-are found in central nervous system regions that receive local RA signals early in development, and retain a significant amount of functional or structural plasticity in the adult. J. Comp. Neurol. 452:228-241, 2002. (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码:228 / 241
页数:14
相关论文
共 85 条
[1]  
ABERLE SBD, 1933, J NUTR, V7, P445
[2]   Neural plasticity and stress induced changes in defense in the rat [J].
Adamec, RE ;
Blundell, J ;
Collins, A .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2001, 25 (7-8) :721-744
[3]   Different modes of hippocampal plasticity in response to estrogen in young and aged female rats [J].
Adams, MM ;
Shah, RA ;
Janssen, WGM ;
Morrison, JH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (14) :8071-8076
[4]   AUTORADIOGRAPHIC AND HISTOLOGICAL STUDIES OF POSTNATAL NEUROGENESIS .4. CELL PROLIFERATION AND MIGRATION IN ANTERIOR FOREBRAIN, WITH SPECIAL REFERENCE TO PERSISTING NEUROGENESIS IN OLFACTORY BULB [J].
ALTMAN, J .
JOURNAL OF COMPARATIVE NEUROLOGY, 1969, 137 (04) :433-&
[5]  
Alvarez-Buylla A, 2000, Prog Brain Res, V127, P1
[6]   NEUROGENESIS AND PLASTICITY IN THE CNS OF ADULT BIRDS [J].
ALVAREZBUYLLA, A .
EXPERIMENTAL NEUROLOGY, 1992, 115 (01) :110-114
[7]  
Anchan RM, 1997, J COMP NEUROL, V379, P171
[8]   DIFFERENT POPULATIONS OF PARVALBUMIN-D28K-IMMUNOREACTIVE AND CALBINDIN-D28K-IMMUNOREACTIVE NEURONS CONTAIN GABA AND ACCUMULATE H-3 D-ASPARTATE IN THE DORSAL HORN OF THE RAT SPINAL-CORD [J].
ANTAL, M ;
POLGAR, E ;
CHALMERS, J ;
MINSON, JB ;
LLEWELLYNSMITH, I ;
HEIZMANN, CW ;
SOMOGYI, P .
JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 314 (01) :114-124
[9]   TRANSGENIC INDICATOR MICE FOR STUDYING ACTIVATED RETINOIC ACID RECEPTORS DURING DEVELOPMENT [J].
BALKAN, W ;
COLBERT, M ;
BOCK, C ;
LINNEY, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) :3347-3351
[10]   Endogenous repair after spinal cord contusion injuries in the rat [J].
Beattie, MS ;
Bresnahan, JC ;
Komon, J ;
Tovar, CA ;
Van Meter, M ;
Anderson, DK ;
Faden, AI ;
Hsu, CY ;
Noble, LJ ;
Salzman, S ;
Young, W .
EXPERIMENTAL NEUROLOGY, 1997, 148 (02) :453-463