Fifty Shades of α-Ketoglutarate on Cellular Programming

被引：18

作者：

Di Conza, Giusy ^{[1
,2
]}

Tsai, Chin-Hsien ^{[1
,2
]}

Ho, Ping-Chih ^{[1
,2
]}

机构：

[1] Univ Lausanne, Dept Fundamental Oncol, Lausanne, Switzerland

[2] Univ Lausanne, Ludwig Inst Canc Res, Epalinges, Switzerland

来源：

MOLECULAR CELL | 2019年 / 76卷 / 01期

关键词：

GLUTAMINE; GROWTH;

D O I：

10.1016/j.molcel.2019.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High plasticity to utilize different nutrients to adapt metabolic stress is one of the hallmarks for cancer cells. However, the underlying mechanisms by which cancer cells reprogram metabolic machinery in response to metabolic stress remain largely unclear. In this issue of Molecular Cell, Wang et al. (2019) report that glutamate dehydrogenase 1 (GDH1) induces an unconventional regulation of the NF-kappa B pathway under glucose deprivation, thereby stimulating glycolysis in glioblastomas.

引用

页码：1 / 3

页数：3