Controlled attenuation parameter using the FibroScan® XL probe for quantification of hepatic steatosis for non-alcoholic fatty liver disease in an Asian population

被引:60
作者
Chan, Wah-Kheong [1 ]
Mustapha, Nik Raihan Nik [2 ]
Wong, Grace Lai-Hung [3 ]
Wong, Vincent Wai-Sun [3 ]
Mahadeva, Sanjiv [1 ]
机构
[1] Univ Malaya, Fac Med, Dept Med, Kuala Lumpur 50603, Malaysia
[2] Hosp Sultanah Bahiyah, Dept Pathol, Langgar, Malaysia
[3] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China
关键词
Non‐ alcoholic fatty liver disease; NAFLD; controlled attenuation parameter; CAP; liver stiffness measurement; LSM; FibroScan; XL probe; steatosis; fibrosis;
D O I
10.1177/2050640616646528
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background The FibroScan (R) XL probe reduces failure of liver stiffness measurement (LSM) and unreliable results in obese patients. Objective The objective of this article is to evaluate the accuracy of controlled attenuation parameter (CAP) obtained using the XL probe for the estimation of hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD). Methods Adult NAFLD patients with a liver biopsy within six months were included and were examined with the FibroScan (R) M and XL probes. Histopathological findings were reported according to the Non-Alcoholic Steatohepatitis Clinical Research Network Scoring System. Participants who did not have fatty liver on ultrasonography were recruited as controls. Results A total of 57 NAFLD patients and 22 controls were included. The mean age of the NAFLD patients and controls was 50.1 +/- 10.4 years and 20.2 +/- 1.3 years, respectively (p = 0.000). The mean body mass index was 30.2 +/- 5.0 kg per m(2) and 20.5 +/- 2.4 kg per m(2), respectively (p = 0.000). The distribution of steatosis grades were: S0, 29%; S1, 17%; S2, 35%; S3, 19%. The AUROC for estimation of steatosis grade >= S1, S2 and S3 was 0.94, 0.80 and 0.69, respectively, using the M probe, and 0.97, 0.81 and 0.67, respectively, using the XL probe. Conclusion CAP obtained using the XL probe had similar accuracy as the M probe for the estimation of hepatic steatosis in NAFLD patients.
引用
收藏
页码:76 / 85
页数:10
相关论文
共 35 条
[1]   The metabolic syndrome - a new worldwide definition [J].
Alberti, KGMM ;
Zimmet, P ;
Shaw, J .
LANCET, 2005, 366 (9491) :1059-1062
[2]   The new BMI criteria for Asians by the regional office for the Western Pacific Region of WHO are suitable for screening of overweight to prevent metabolic syndrome in elder Japanese workers [J].
Anuurad, E ;
Shiwaku, K ;
Nogi, A ;
Kitajima, K ;
Enkhmaa, B ;
Shimono, K ;
Yamane, Y .
JOURNAL OF OCCUPATIONAL HEALTH, 2003, 45 (06) :335-343
[3]   Determination of reliability criteria for liver stiffness evaluation by transient elastography [J].
Boursier, Jerome ;
Zarski, Jean-Pierre ;
de Ledinghen, Victor ;
Rousselet, Marie-Christine ;
Sturm, Nathalie ;
Lebail, Brigitte ;
Fouchard-Hubert, Isabelle ;
Gallois, Yves ;
Oberti, Frederic ;
Bertrais, Sandrine ;
Cales, Paul .
HEPATOLOGY, 2013, 57 (03) :1182-1191
[4]   The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association [J].
Chalasani, Naga ;
Younossi, Zobair ;
Lavine, Joel E. ;
Diehl, Anna Mae ;
Brunt, Elizabeth M. ;
Cusi, Kenneth ;
Charlton, Michael ;
Sanyal, Arun J. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2012, 107 (06) :811-826
[5]   A novel 2-step approach combining the NAFLD fibrosis score and liver stiffness measurement for predicting advanced fibrosis [J].
Chan, Wah-Kheong ;
Mustapha, Nik Raihan Nik ;
Mahadeva, Sanjiv .
HEPATOLOGY INTERNATIONAL, 2015, 9 (04) :594-602
[6]   Controlled attenuation parameter for the detection and quantification of hepatic steatosis in nonalcoholic fatty liver disease [J].
Chan, Wah-Kheong ;
Mustapha, Nik Raihan Nik ;
Mahadeva, Sanjiv .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2014, 29 (07) :1470-1476
[7]   Non-alcoholic fatty liver disease in a young multiracial Asian population: a worrying ethnic predilection in Malay and Indian males [J].
Chan, Wah-Kheong ;
Bahar, Norhaniza ;
Razlan, Hamizah ;
Vijayananthan, Anushya ;
Sithaneshwar, Pavai ;
Goh, Khean-Lee .
HEPATOLOGY INTERNATIONAL, 2014, 8 (01) :121-127
[8]   Non-alcoholic fatty liver disease in diabetics - prevalence and predictive factors in a multiracial hospital clinic population in Malaysia [J].
Chan, Wah-Kheong ;
Tan, Alexander Tong-Boon ;
Vethakkan, Shireene Ratna ;
Tah, Pei-Chien ;
Vijayananthan, Anushya ;
Goh, Khean-Lee .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2013, 28 (08) :1375-1383
[9]   Controlled attenuation parameter (CAP) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population [J].
Chon, Young Eun ;
Jung, Kyu Sik ;
Kim, Seung Up ;
Park, Jun Yong ;
Park, Young Nyun ;
Kim, Do Young ;
Ahn, Sang Hoon ;
Chon, Chae Yoon ;
Lee, Hye Won ;
Park, Yehyun ;
Han, Kwang-Hyub .
LIVER INTERNATIONAL, 2014, 34 (01) :102-109
[10]   Controlled attenuation parameter (CAP) for the diagnosis of steatosis: A prospective study of 5323 examinations [J].
de Ledinghen, Victor ;
Vergniol, Julien ;
Capdepont, Maylis ;
Chermak, Faiza ;
Hiriart, Jean-Baptiste ;
Cassinotto, Christophe ;
Merrouche, Wassil ;
Foucher, Juliette ;
Brigitte, Le Bail .
JOURNAL OF HEPATOLOGY, 2014, 60 (05) :1026-1031