Hydrogels in endovascular embolization .6. Toxicity tests of poly(2-hydroxyethyl methacrylate) particles on cell cultures

被引：36
|
作者：
Horak, D [1 ]
Cervinka, M [1 ]
Puza, V [1 ]
机构：
[1] CHARLES UNIV,FAC MED,HRADEC KRALOVE 50001,CZECH REPUBLIC
来源：
BIOMATERIALS | 1997年 / 18卷 / 20期
关键词：
poly(2-hydroxyethyl methacrylate); hydrogels; cytotoxicity; contact test; extraction test; cell proliferation;
D O I：
10.1016/S0142-9612(97)00059-8
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Cytotoxicity of poly(2-hydroxyethyl methacrylate) [poly(HEMA)] hydrogel spherical particles, prepared by radical suspension polymerization and designed for endovascular occlusion, was studied in vitro on cell cultures. Testing methods included a direct contact test and extraction test. No inhibition of growth of cells surrounding the poly(HEMA) beads and a Very low inhibition of cell viability, only in concentrated extracts in long-term contact, were observed. As a result, poly(HEMA) beads can be considered non-toxic. (C) 1997 Elsevier Science Limited. All rights reserved.
引用
收藏
页码：1355 / 1359
页数：5
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