The Roles of Integrin α5β1 in Human Cancer

被引：87

作者：

Hou, Jianbing ^{[1
,2
,3
]}

Yan, Du ^{[4
]}

Liu, Yudong ^{[1
,2
,3
]}

Huang, Pan ^{[1
,2
,3
]}

Cui, Hongjuan ^{[1
,2
,3
]}

机构：

[1] Southwest Univ, State Key Lab Silkworm Genome Biol, Key Lab Sericulture Biol & Genet Breeding, Minist Agr & Rural Affairs, Chongqing 400716, Peoples R China

[2] Southwest Univ, Canc Ctr, Med Res Inst, Chongqing 400716, Peoples R China

[3] Chongqing Engn & Technol Res Ctr Silk Biomat & Re, Chongqing 400716, Peoples R China

[4] Chongqing Univ, Chongqing Emergency Med Ctr, Cent Hosp, Chongqing 400716, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2020年 / 13卷

基金：

中国国家自然科学基金;

关键词：

integrin alpha 5 beta 1; prognostic indicator; tumorigenesis; molecular target; SQUAMOUS-CELL CARCINOMA; EXTRACELLULAR-MATRIX PROTEINS; NF-KAPPA-B; ALPHA(5)BETA(1) INTEGRIN; DRUG-RESISTANCE; GENE-EXPRESSION; TUMOR-GROWTH; LUNG-CANCER; MESENCHYMAL TRANSITION; ENDOTHELIAL ALPHA-5;

D O I：

10.2147/OTT.S273803

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cell adhesion to the extracellular matrix has important roles in tissue integrity and human health. Integrins are heterodimeric cell surface receptors that are composed by two non-covalently linked alpha and beta subunits that mainly participate in the interaction of cell-cell adhesion and cell-extracellular matrix and regulate cell motility, adhesion, differentiation, migration, proliferation, etc. In mammals, there have been eighteen alpha subunits and 8 beta subunits and so far 24 distinct types of alpha beta integrin heterodimers have been identified in humans. Integrin alpha 5 beta 1, also known as the fibronectin receptor, is a heterodimer with alpha 5 and beta 1 subunits and has emerged as an essential mediator in many human carcinomas. Integrin alpha 5 beta 1 alteration is closely linked to the progression of several types of human cancers, including cell proliferation, angiogenesis, tumor metastasis, and cancerogenesis. In this review, we will introduce the functions of integrin alpha 5 beta 1 in cancer progression and also explore its regulatory mechanisms. Additionally, the potential clinical applications as a target for cancer imaging and therapy are discussed. Collectively, the information reviewed here may increase the understanding of integrin alpha 5 beta 1 as a potential therapeutic target for cancer.

引用

页码：13329 / 13344

页数：16

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