Genome-based pharmacogenetics and the pharmaceutical industry

被引：104
作者：
Roses, AD [1 ]
机构：
[1] GlaxoSmithKline, Genet Res, Res Triangle Pk, NC 27709 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 07期
关键词：
D O I：
10.1038/nrd840
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Pharmacogenetic capabilities have changed markedly since The SNP Consortium made a dense single-nucleotide polymorphism (SNP) map freely available in 2001. For more than 40 years, pharmacokinetics and pharmacodynamics of drug-metabolizing molecules were the focus of practical applications. Today, it is possible to use SNP-mapping technologies to create a genetic profile of each individual that can be used to identify patterns of susceptibility genes for common diseases as well as genetic risk/efficacy factors that are related to the effects of drugs.
引用
收藏
页码：541 / 549
页数：9
相关论文
共 51 条
[1]   ANALYSIS OF GENES FOR BILIRUBIN UDP-GLUCURONOSYLTRANSFERASE IN GILBERTS-SYNDROME [J].
AONO, S ;
ADACHI, Y ;
UYAMA, E ;
YAMADA, Y ;
KEINO, H ;
NANNO, T ;
KOIWAI, O ;
SATO, H .
LANCET, 1995, 345 (8955) :958-959
[2]   Patterns of linkage disequilibrium in the human genome [J].
Ardlie, KG ;
Kruglyak, L ;
Seielstad, M .
NATURE REVIEWS GENETICS, 2002, 3 (04) :299-309
[3]  
Bergstresser P R, 1989, Immunol Ser, V46, P219
[4]   THE GENETIC-BASIS OF THE REDUCED EXPRESSION OF BILIRUBIN UDP-GLUCURONOSYLTRANSFERASE-1 IN GILBERTS-SYNDROME [J].
BOSMA, PJ ;
CHOWDHURY, JR ;
BAKKER, C ;
GANTLA, S ;
DEBOER, A ;
OOSTRA, BA ;
LINDHOUT, D ;
TYTGAT, GNJ ;
JANSEN, PLM ;
ELFERINK, RPJO ;
CHOWDHURY, NR .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (18) :1171-1175
[5]   SEQUENCE OF EXONS AND THE FLANKING REGIONS OF HUMAN BILIRUBIN-UDP-GLUCURONOSYLTRANSFERASE GENE-COMPLEX AND IDENTIFICATION OF A GENETIC MUTATION IN A PATIENT WITH CRIGLER-NAJJAR SYNDROME, TYPE-I [J].
BOSMA, PJ ;
CHOWDHURY, NR ;
GOLDHOORN, BG ;
HOFKER, MH ;
ELFERINK, RPJO ;
JANSEN, PLM ;
CHOWDHURY, JR .
HEPATOLOGY, 1992, 15 (05) :941-947
[6]  
BREW BJ, 1998, 12 WORLD AIDS C, P192
[7]   Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy [J].
Brinkman, K ;
Smeitink, JA ;
Romijn, JA ;
Reiss, P .
LANCET, 1999, 354 (9184) :1112-1115
[8]  
BUCHANAN A, IN PRESS KENNEDY I E
[9]  
CANTOR C, 2002, HUMAN GENOME OR 0531
[10]   Testing drug response in the presence of genetic information: sampling issues for clinical trials [J].
Cardon, LR ;
Idury, RM ;
Harris, TJR ;
Witte, JS ;
Elston, RC .
PHARMACOGENETICS, 2000, 10 (06) :503-510
123456