Design and Application of Receptor-Targeted Fluorescent Probes Based on Small Molecular Fluorescent Dyes

被引：58

作者：

Zhang, Yujie ^{[1
,2
]}

Li, Shufeng ^{[1
,2
]}

Zhang, Hang ^{[1
,2
]}

Xu, Haiwei ^{[1
,2
]}

机构：

[1] Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Minist Educ, Coinnovat Ctr Henan Prov New Drug R&D & Preclin S, Zhengzhou 450001, Henan, Peoples R China

[2] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China

来源：

BIOCONJUGATE CHEMISTRY | 2021年 / 32卷 / 01期

基金：

中国国家自然科学基金;

关键词：

IN-VIVO; GUIDED SURGERY; IMAGING PROBE; BREAST-CANCER; SELECTIVE VISUALIZATION; OVARIAN-CANCER; INFLAMMATION; EXPRESSION; CYCLOOXYGENASE-2; LIGANDS;

D O I：

10.1021/acs.bioconjchem.0c00606

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, a variety of receptor-targeted fluorescent probes have been developed and widely used to realize the visualization of certain receptors, which facilitates the early diagnosis and treatment of diseases. In this Review, we focus on the recent achievements in design, chemical structure, imaging characterization, and potential applications of receptor-targeted fluorescent probes from the past 10 years. The development and application of receptor-targeted fluorescent probes will expand our knowledge of the distribution and function of disease-related receptors, shed light on the drug discovery for clinical diseases where receptors are implicated, and feed into the diagnosis and treatment of a plethora of diseases, including tumors.

引用

页码：4 / 24

页数：21

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