Natural carbon-based quantum dots and their applications in drug delivery: A review

被引：200

作者：

Nair, Akhila ^{[1
]}

Haponiuk, Jozef T. ^{[1
]}

Thomas, Sabu ^{[2
]}

Gopi, Sreeraj ^{[1
]}

机构：

[1] Gdansk Univ Technol, Dept Chem, Gdansk, Poland

[2] Mahatma Gandhi Univ, Sch Chem Sci, Kottayam, Kerala, India

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 132卷

关键词：

Natural carbon quantum dots; Synthesis; Optical mechanism; Drug delivery applications; Clinical status; MICROWAVE-ASSISTED SYNTHESIS; GREEN SYNTHESIS; ONE-STEP; PHYSICOCHEMICAL PROPERTIES; ANTIMICROBIAL ACTIVITY; IN-VITRO; CELL; FLUORESCENCE; LUMINESCENT; NANOPARTICLES;

D O I：

10.1016/j.biopha.2020.110834

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Natural carbon based quantum dots (NCDs) are an emerging class of nanomaterials in the carbon family. NCDs have gained immense acclamation among researchers because of their abundance, eco-friendly nature, aqueous solubility, the diverse functionality and biocompatibility when compared to other conventional carbon quantum dots (CDs).The presence of different functional groups on the surface of NCDs such as thiol, carboxyl, hydroxyl, etc., provides improved quantum yield, physicochemical and optical properties which promote bioimaging, sensing, and drug delivery. This review provides comprehensive knowledge about NCDs for drug delivery ap-plications by outlining the source and rationale behind NCDs, different routes of synthesis of NCDs and the merits of adopting each method. Detailed information regarding the mechanism behind the optical properties, toxicological profile including biosafety and biodistribution of NCDs that are favourable for drug delivery are discussed. The drug delivery applications of NCDs particularly as sensing and real-time tracing probe, antimicrobial, anticancer, neurodegenerative agents are reviewed. The clinical aspects of NCDs are also reviewed as an initiative to strengthen the case of NCDs as potent drug delivery agents.

引用

页数：15

共 111 条

[1]

Aji MP, 2017, J THEOR APPL PHYS, V11, P119, DOI 10.1007/s40094-017-0250-3

[2] Green and cost-effective synthesis of carbon dots from date kernel and their application as a novel switchable fluorescence probe for sensitive assay of Zoledronic acid drug in human serum and cellular imaging [J].