Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 2: Treatment

被引：10

作者：

Barreiro-de Acosta, Manuel ^{[1
]}

Marin-Jimenez, Ignacio ^{[2
]}

Rodriguez-Lago, Iago ^{[3
,4
]}

Guarner, Francisco ^{[5
]}

Espin, Eloy ^{[6
]}

Ferrer Bradley, Isabel ^{[7
]}

Gutierrez, Ana ^{[8
,9
]}

Beltran, Belen ^{[9
,10
]}

Chaparro, Maria ^{[9
,11
]}

Gisbert, Javier P. ^{[9
,11
]}

Nos, Pilar ^{[9
,10
]}

机构：

[1] Hosp Clin Univ Santiago, Serv Aparato Digest, Unidad EII, Santiago De Compostela, Spain

[2] Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon IiSGM, Serv Aparato Digest, Madrid, Spain

[3] Hosp Galdakao, Serv Aparato Digest, Unidad EII, Galdakao, Spain

[4] Inst Invest Sanitaria Biocruces Bizkaia, Baracaldo, Spain

[5] Vall dHebron Inst Recerca VHIR, Grp Fisiol & Fisiopatol Digest, Barcelona, Spain

[6] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Serv Cirugia Gen, Unidad Cirugia Colorrectal, Barcelona, Spain

[7] Hosp Manises, Serv Med Digest, Unidad EII, Valencia, Spain

[8] Hosp Gen Univ Alicante, Serv Med Digest, Alicante, Spain

[9] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain

[10] Hosp Univ & Politecn La Fe, Serv Med Digest, Unidad EII, Valencia, Spain

[11] Univ Autonoma Madrid, Hosp Univ La Princesa, Inst Invest Sanitaria Princesa IIS IP, Serv Aparato Digest, Madrid, Spain

来源：

GASTROENTEROLOGIA Y HEPATOLOGIA | 2020年 / 43卷 / 10期

关键词：

Ulcerative colitis; Inflammatory bowel disease; Pouchitis; CHRONIC REFRACTORY POUCHITIS; QUALITY-OF-LIFE; DOUBLE-BLIND; ANAL ANASTOMOSIS; RESTORATIVE PROCTOCOLECTOMY; ILEOANAL POUCH; ANTISENSE INHIBITOR; THERAPY; PLACEBO; COMPLICATIONS;

D O I：

10.1016/j.gastrohep.2020.04.004

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pouchitis treatment is a complex entity that requires a close medical and surgical relationship. The elective treatment for acute pouchitis is antibiotics. After a first episode of pouchitis it is recommended prophylaxis therapy with a probiotic mix, nevertheless it is not clear the use of this formulation for preventing a first episode of pouchitis after surgery. First-line treatment for chronic pouchitis is an antibiotic combination. The next step in treatment should be oral budesonide. Selected cases of severe, chronic refractory pouchitis may benefit from biologic agents, and anti-TNF alpha should be recommended as the first option, leaving the new biologicals for multi-refractory patients. Permanent ileostomy may be an option in severe refractory cases to medical treatment. (C) 2020 The Author(s). Published by Elsevier Espana, S.L.U.

引用

页码：649 / 658

页数：10

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