Fas and Fas ligand in gut and liver

被引:132
作者
Pinkoski, MJ
Brunner, T
Green, DR
Lin, T
机构
[1] La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
[2] Univ Bern, Inst Pathol, Div Immunopathol, CH-3010 Bern, Switzerland
来源
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2000年 / 278卷 / 03期
关键词
apoptosis; intestine; colitis; hepatitis; transplant;
D O I
10.1152/ajpgi.2000.278.3.G354
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Apoptosis (programmed cell death) has been shown to play a major role in development and in the pathogenesis of numerous diseases. A principal mechanism of apoptosis is molecular interaction between surface molecules known as the "death receptors" and their ligands. Perhaps the best-studied death receptor and ligand system is the Fas/Fas ligand (FasL) system, in which Fast, a member of the tumor necrosis factor (TNF) family of death-inducing ligands, signals death through the death receptor Fas, thereby resulting in the apoptotic death of the cell. Numerous cells in the liver and gastrointestinal tract have been shown to express Fas/FasL, and there is a growing body of evidence that the Fas/FasL System plays a major role in the pathogenesis of many liver and gastrointestinal. diseases, such as inflammatory bowel disease, graft vs. host disease, and hepatitis. Here we review the Fas/FasL system and the evidence that it is involved in the pathogenesis of liver and gastrointestinal diseases.
引用
收藏
页码:G354 / G366
页数:13
相关论文
共 150 条
  • [31] A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
    Enari, M
    Sakahira, H
    Yokoyama, H
    Okawa, K
    Iwamatsu, A
    Nagata, S
    [J]. NATURE, 1998, 391 (6662) : 43 - 50
  • [32] Spontaneous liver graft acceptance is mediated by intragraft Fas-ligand expression and viable passenger leukocytes
    Fändrich, F
    Lin, X
    Zhu, X
    Parwaresch, R
    Kremer, B
    Henne-Bruns, D
    [J]. TRANSPLANTATION PROCEEDINGS, 1998, 30 (05) : 2360 - 2361
  • [33] Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas
    Faubion, WA
    Guicciardi, ME
    Miyoshi, H
    Bronk, SF
    Roberts, PJ
    Svingen, PA
    Kaufmann, SH
    Gores, GJ
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (01) : 137 - 145
  • [34] A vision of cell death: Insights into immune privilege
    Ferguson, TA
    Griffith, TS
    [J]. IMMUNOLOGICAL REVIEWS, 1997, 156 : 167 - 184
  • [35] FERRARA JLM, 1991, NEW ENGL J MED, V324, P667
  • [36] Apoptosis mediated by Fas but not tumor necrosis factor receptor 1 prevents chronic disease in mice infected with murine cytomegalovirus
    Fleck, M
    Kern, ER
    Zhou, T
    Podlech, J
    Wintersberger, W
    Edwards, CK
    Mountz, JD
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (07) : 1431 - 1443
  • [37] Fas and Fas ligand in embryos and adult mice: Ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover
    French, LE
    Hahne, M
    Viard, I
    Radlgruber, G
    Zanone, R
    Becker, K
    Muller, C
    Tschopp, J
    [J]. JOURNAL OF CELL BIOLOGY, 1996, 133 (02) : 335 - 343
  • [38] CD95-induced apoptosis in human liver disease
    Galle, PR
    Krammer, PH
    [J]. SEMINARS IN LIVER DISEASE, 1998, 18 (02) : 141 - 151
  • [39] INVOLVEMENT OF THE CD95 (APO-1/FAS) RECEPTOR AND LIGAND IN LIVER-DAMAGE
    GALLE, PR
    HOFMANN, WJ
    WALCZAK, H
    SCHALLER, H
    OTTO, G
    STREMMEL, W
    KRAMMER, PH
    RUNKELL, L
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (05) : 1223 - 1230
  • [40] Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis
    Gao, YK
    Herndon, JM
    Zhang, H
    Griffith, TS
    Ferguson, TA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (05) : 887 - 896