Automated analysis of protein NMR assignments and structures

被引：76

作者：

Baran, MC

Huang, YJ

Moseley, HNB

Montelione, GT

机构：

[1] Rutgers State Univ, Ctr Adv Biotechnol & Med, Dept Biochem & Mol Biol, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, NE Struct Genomics Consortium, Piscataway, NJ 08854 USA

[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Biochem & Mol Biol, Piscataway, NJ 08854 USA

来源：

CHEMICAL REVIEWS | 2004年 / 104卷 / 08期

关键词：

D O I：

10.1021/cr030408p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent developments provide automated analysis of NMR assignments and 3D structures. These approaches are generally applicable to proteins ranging from about 50 to 150 amino acids. To date, little work has focused on the specific problems associated with nucleic acid structures. As a result, there has been no community-wide consensus reached on how to evaluate the accuracy and precision of a protein NMR structure. Nevertheless, when good quality data are available automated analysis of protein NMR assignment and structures can be both fast and reliable.

引用

页码：3541 / 3555

页数：15

共 146 条

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