Re-irradiation in lung disease by SBRT: a retrospective, single institutional study

被引：14
作者：
Caivano, Donatella [1 ]
Valenani, Maurizio [2 ]
De Matteis, Sara [2 ]
Bonome, Paolo [2 ]
Russo, Ivana [3 ]
De Sanctis, Vitaliana [2 ]
Minniti, Giuseppe [4 ]
Osti, Mattia Falchetto [2 ]
机构：
[1] CNAO Natl Ctr Oncol Hadrontherapy, Dept Radiat Oncol, Str Campeggi 53, I-27100 Pavia, Italy
[2] Univ Rome Sapienza, St Andrea Hosp, Fac Med & Psicol, Dept Radiat Oncol, Via Grottarossa 1035-1039, I-00189 Rome, Italy
[3] UPMC San Pietro FBF, Ctr Radioterapia Alta Specializzaz, Via Cassia 600, I-00189 Rome, Italy
[4] Neuromed Mediterranean Neurol Inst, Via Atinense 18, I-86077 Pozzilli, IS, Italy
来源：
RADIATION ONCOLOGY | 2018年 / 13卷
关键词：
Re-irradiation; SBRT; Lung; Primary or metastatic disease; STEREOTACTIC ABLATIVE RADIOTHERAPY; RADIATION-THERAPY; CANCER; TUMORS;
D O I：
10.1186/s13014-018-1041-y
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The loco regional relapse is frequent in the lung disease. The aim of this study was to evaluate the outcomes of re-irradiation by SBRT in terms of Local Control (LC) and toxicities. Methods: From April 2011 to December 2016, twenty-two patients received a re-irradiation by SBRT. Twenty-seven lesions were treated. The medium BED(10) of re-irradiation was 100.6 Gy (range: 48-151.2 Gy) and the medium EQD2 (10) was 93.8 Gy (range: 40-126 Gy). In the previous treatment the medium BED(10) was 97.2 Gy (range: 40-120 Gy), the medium EQD2(10) was 81 Gy (range: 32.5-100 Gy). The median time between the first and the second treatment was 18 months. Results: Local Control was reached in 18 out of 27 (66%) re-irradiated lesions, with rates of 67 and 54% at 1-year and 2-years respectively. The treatment was well tolerated; the maximum recorded toxicity was Grade 3. Conclusions: Re-irradiation by SBRT may represent an option for the treatment of lung disease with good results in terms of LC and toxicity.
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页数：8
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