Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines

被引：20
作者：
Beyreuther, K
Multhaup, G
Monning, U
Sandbrink, R
Beher, D
Hesse, L
Small, DH
Masters, CL
机构：
[1] UNIV MELBOURNE,DEPT PATHOL,PARKVILLE,VIC 3052,AUSTRALIA
[2] MENTAL HLTH RES INST,PARKVILLE,VIC 3052,AUSTRALIA
来源：
NEUROBIOLOGY OF ALZHEIMER'S DISEASE | 1996年 / 777卷
关键词：
D O I：
10.1111/j.1749-6632.1996.tb34403.x
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have identified and characterized the ligand binding properties of the Alzheimer's disease (AD) beta A4 amyloid protein precursor (APP), mapped the APP ligand binding sites and analyzed the regulation of APP expression, biogenesis and metabolism by components of the extracellular matrix (ECM) and cytokines.
引用
收藏
页码：74 / 76
页数：3
相关论文
共 17 条
[1]   EARLY AND RAPID DE-NOVO SYNTHESIS OF ALZHEIMER BETA-A4-AMYLOID PRECURSOR PROTEIN (APP) IN ACTIVATED MICROGLIA [J].
BANATI, RB ;
GEHRMANN, J ;
CZECH, C ;
MONNING, U ;
JONES, LL ;
KONIG, G ;
BEYREUTHER, K ;
KREUTZBERG, GW .
GLIA, 1993, 9 (03) :199-210
[2]  
BUSH AI, 1993, J BIOL CHEM, V268, P16109
[3]  
DYRKS T, 1992, J BIOL CHEM, V267, P18210
[4]   AMYLOIDOGENICITY OF RODENT AND HUMAN BETA-A4 SEQUENCES [J].
DYRKS, T ;
DYRKS, E ;
MASTERS, CL ;
BEYREUTHER, K .
FEBS LETTERS, 1993, 324 (02) :231-236
[5]   THE BETA-A4 AMYLOID PRECURSOR PROTEIN-BINDING TO COPPER [J].
HESSE, L ;
BEHER, D ;
MASTERS, CL ;
MULTHAUP, G .
FEBS LETTERS, 1994, 349 (01) :109-116
[6]  
KONIG G, 1992, J BIOL CHEM, V267, P10804
[7]   TRANSFORMING GROWTH-FACTOR-BETA MEDIATES INCREASE OF MATURE TRANSMEMBRANE AMYLOID PRECURSOR PROTEIN IN MICROGLIAL CELLS [J].
MONNING, U ;
SANDBRINK, R ;
BANATI, RB ;
MASTERS, CL ;
BEYREUTHER, K .
FEBS LETTERS, 1994, 342 (03) :267-272
[8]   EXTRACELLULAR-MATRIX INFLUENCES THE BIOGENESIS OF AMYLOID PRECURSOR PROTEIN IN MICROGLIAL CELLS [J].
MONNING, U ;
SANDBRINK, R ;
WEIDEMANN, A ;
BANATI, RB ;
MASTERS, CL ;
BEYREUTHER, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (13) :7104-7110
[9]  
MONNING U, 1992, J BIOL CHEM, V267, P23950
[10]   IDENTIFICATION AND REGULATION OF THE HIGH-AFFINITY BINDING-SITE OF THE ALZHEIMERS-DISEASE AMYLOID PROTEIN-PRECURSOR (APP) TO GLYCOSAMINOGLYCANS [J].
MULTHAUP, G .
BIOCHIMIE, 1994, 76 (3-4) :304-311
12