Protection against neurodegenerative diseases of Iris pseudopumila extracts and their constituents

被引：52
作者：
Conforti, Filornena [1 ]
Rigano, Daniela [2 ]
Menichini, Federica [3 ]
Loizzo, Monica Rosa [1 ]
Senatore, Felice [2 ]
机构：
[1] Univ Calabria, Dept Pharmaceut Sci, I-87036 Arcavacata Di Rende, CS, Italy
[2] Univ Naples Federico II, Dept Chem Nat Prod, I-80131 Naples, Italy
[3] Kings Coll London, Pharmacognosy Res Labs, Dept Pharm, London SE1, England
来源：
FITOTERAPIA | 2009年 / 80卷 / 01期
关键词：
Iris pseudopumila Tineo; Iridaceae; Phenolic compounds; Anti-inflammatory activity; Alzheimer's disease; CENTRAL-NERVOUS-SYSTEM; IN-VITRO ACTIVITIES; ALZHEIMERS-DISEASE; NITRIC-OXIDE; ANTIOXIDANT PROPERTIES; FLAVONOIDS; GERMANICA; RHIZOMES; ACETYLCHOLINESTERASE; ISOFLAVONOIDS;
D O I：
10.1016/j.fitote.2008.10.005
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The present study describes for the first time the in vitro properties of Iris pseudopumila flowers and rhizomes extracts and their constituents. The methanolic extract of rhizomes showed significant anti-inflammatory activity through inhibition of NO production in the murine monocytic macrophage cell line RAW 264.7. Among the isolated compounds, those which most effectively inhibited LPS-induced NO production were irisolidone and 7-methyl-tectorigenin-4'-O-[beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranoside], with IC50 values of 23.6 mu M and 29.4 mu M respectively. Isoorientin and isovitexin exhibited the most promising activity against AChE with IC50 of 26.8 mu M and 36.4 mu M, respectively. The same compounds exhibited also the higher activity against BChE. (C) 2008 Elsevier B.V. All rights reserved.
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收藏
页码：62 / 67
页数：6
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