Can We Cure Atherosclerosis?

被引：20

作者：

Robinson, Jennifer G. ^{[1
,2
,3
]}

Davidson, Michael H. ^{[4
]}

机构：

[1] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Med, Coll Publ Hlth, Iowa City, IA 52242 USA

[3] Carver Coll Med, Iowa City, IA 52242 USA

[4] Univ Chicago Med, Dept Cardiol, Chicago, IL USA

来源：

REVIEWS IN CARDIOVASCULAR MEDICINE | 2018年 / 19卷

关键词：

Atherosclerosis; Regression; Primary prevention; Familial hypercholesterolemia; Apolipoprotein B lipoproteins; PCSK9 monoclonal antibodies; Statins; LONG-TERM RISK; FAMILIAL HYPERCHOLESTEROLEMIA; LDL CHOLESTEROL; STATIN THERAPY; EFFICACY; SAFETY; DISEASE; METAANALYSIS; PROGRESSION; EVOLOCUMAB;

D O I：

10.3909/ricm19S1S0003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular disease mortality rates have begun to rise in the United States. Based on the large body of supportive evidence, we propose a proof-of-concept, first-in-human trial to cure atherosclerosis: CURing Early ATHEROsclerosis (CURE ATHERO). This trial is based on a model of intensive induction therapy for extensive, if not complete, plaque regression, followed by intermittent maintenance therapy. An extensive body of evidence has demonstrated the causal role of apolipoprotein B lipoproteins in atherosclerosis progression and data suggest intensive low-density lipoprotein cholesterol (LDL-C) lowering may have a substantial impact on earlier stages of atherosclerosis. Compared with lifetime treatment to prevent atherosclerosis progression, this induction-intermittent treatment model will minimize costs and maximize adherence and safety. (C) 2018 MedReviews (R), LLC

引用

页码：S20 / S24

页数：5

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