A palladium/norbornene cooperative catalysis to access N-containing bridged scaffolds

被引：30

作者：

Gao, Qianwen ^{[1
]}

Liu, Ze-Shui ^{[1
]}

Hua, Yu ^{[1
]}

Li, Lisha ^{[1
]}

Cheng, Hong-Gang ^{[1
]}

Cong, Hengjiang ^{[1
]}

Zhou, Qianghui ^{[1
,2
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Sauvage Ctr Mol Sci, Engn Res Ctr Organosilicon Cpds & Mat,Minist Educ, Wuhan 430072, Hubei, Peoples R China

[2] Wuhan Univ, Inst Adv Studies, Wuhan 430072, Hubei, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 60期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

C-H FUNCTIONALIZATION; TETRASUBSTITUTED HELICAL ALKENES; ARYL IODIDES; AROMATIC FUNCTIONALIZATION; SEQUENTIAL REACTIONS; CATELLANI REACTION; ALPHA-ARYLATION; PALLADIUM; NORBORNENE; PD;

D O I：

10.1039/c9cc03126j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium/norbornene cooperative catalysis promoted annulation involving an ortho-C-H amination and intramolecular Heck cascade between aryl iodides and functionalized amination reagents is reported, thereby providing a highly convergent access to the unique N-containing bridged scaffolds: hexahydro-2,6-methano-1-benzazocine. The salient features of the reaction include its broad substrate scope (with respect to aryl iodides), its high step economy, and good chemoselectivity. Preliminary studies underscore the future promise of rendering this Catellani-type annulation enantioselective.

引用

页码：8816 / 8819

页数：4

共 64 条

[1] Palladium/Norbornene-Catalyzed C-H Alkylation/Alkyne Insertion/Indole Dearomatization Domino Reaction: Assembly of Spiroindolenine-Containing Pentacyclic Frameworks [J].