Immunoregulatory functions of VISTA

被引：175

作者：

Nowak, Elizabeth C. ^{[1
]}

Lines, J. Louise ^{[1
]}

Varn, Frederick S. ^{[2
,3
]}

Deng, Jie ^{[1
]}

Sarde, Aurelien ^{[1
]}

Mabaera, Rodwell ^{[1
]}

Kuta, Anna ^{[1
]}

Le Mercier, Isabelle ^{[4
]}

Cheng, Chao ^{[2
,3
]}

Noelle, Randolph J. ^{[1
]}

机构：

[1] Geisel Sch Med Dartmouth, Norris Cotton Canc Ctr, Dept Microbiol & Immunol, Lebanon, NH USA

[2] Geisel Sch Med Dartmouth, Norris Cotton Canc Ctr, Dept Biomed Data Sci, Lebanon, NH USA

[3] Geisel Sch Med Dartmouth, Norris Cotton Canc Ctr, Dept Mol & Syst Biol, Lebanon, NH USA

[4] ImmuNext Inc, Lebanon, NH USA

来源：

IMMUNOLOGICAL REVIEWS | 2017年 / 276卷 / 01期

关键词：

cancer; immunotherapies; PD-1H; VISTA; T-CELL-ACTIVATION; IMMUNE CHECKPOINT BLOCKADE; CROSS-LINKING ANTIBODY; EMBRYONIC STEM-CELLS; TUMOR-BEARING MICE; SUPPRESSOR-CELLS; REGULATORY T; CTLA-4; BLOCKADE; ANTITUMOR IMMUNITY; CANCER-IMMUNOTHERAPY;

D O I：

10.1111/imr.12525

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Utilization of negative checkpoint regulators (NCRs) for cancer immunotherapy has garnered significant interest with the completion of clinical trials demonstrating efficacy. While the results of monotherapy treatments are compelling, there is increasing emphasis on combination treatments in an effort to increase response rates to treatment. One of the most recently discovered NCRs is VISTA (V-domain Ig-containing Suppressor of T cell Activation). In this review, we describe the functions of this molecule in the context of cancer immunotherapy. We also discuss factors that may influence the use of anti-VISTA antibody in combination therapy and how genomic analysis may assist in providing indications for treatment.

引用

页码：66 / 79

页数：14

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