Convenient divergent synthesis of a library of trehalosamine analogues

被引：30

作者：

Hui, Y ^{[1
]}

Chang, CWT ^{[1
]}

机构：

[1] Utah State Univ, Dept Chem & Biochem, Logan, UT 84322 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 13期

关键词：

D O I：

10.1021/ol026095m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of seven trehalosamine analogues with various natural and non-natural binding motifs was synthesized through an expedient divergent synthetic approach, The final products were prepared in sufficient quantities and purities for different types of assay against various pathogens. Several stereo- and regioselective reactions on the trehalose scaffold were developed for rapid synthesis of all of the designed compounds.

引用

页码：2245 / 2248

页数：4

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