Multicomponent Synthesis of Bicyclic Thiazolidinethiones and Oxazolidinones in Water

被引：6

作者：

Stalling, Timo ^{[1
]}

Pauly, Jan ^{[1
]}

Schmidtmann, Marc ^{[1
]}

Martens, Juergen ^{[1
]}

机构：

[1] Carl von Ossietzky Univ Oldenburg, Inst Chem, D-26111 Oldenburg, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 04期

关键词：

Synthetic methods; Multicomponent reactions; Water chemistry; Carbon dioxide; Heterocycles; CHIRAL AUXILIARIES; FACILE SYNTHESIS; ALDOL ADDITIONS; ACID;

D O I：

10.1002/ejoc.201301213

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A powerful three-component reaction for the synthesis of bicyclic thiazolidinethiones and oxazolidinones at room temp. in water, starting from readily available amines, chloroacetaldehyde, and CS2/CO2, is described. A simple one-pot procedure allows the construction of two new cyclic systems and four new bonds, with all reactants being efficiently utilized in this transformation. KHCO3 is used as a productive source of CO2. Broad potential for derivatization is demonstrated.

引用

页码：833 / 843

页数：11

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