Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review

被引：27
作者：
Xu, Yayun [1 ,2 ,3 ]
Chen, Feihu [1 ,2 ,3 ]
机构：
[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 81 Meishan Rd, Hefei 230032, Peoples R China
[2] Anhui Med Univ, Sch Pharm, Anhui Inst Innovat Drugs, Key Lab Major Autoimmune Dis Anhui Prov, Hefei, Peoples R China
[3] Minist Educ, Key Lab Antiinflammatory & Immune Med, Hefei, Peoples R China
来源：
JOURNAL OF INFLAMMATION RESEARCH | 2020年 / 13卷
基金：
中国国家自然科学基金;
关键词：
antioxidant; anti-inflammatory; anti-apoptotic; nesfatin-1; anorexigenic; BLOOD-BRAIN-BARRIER; ACUTE LUNG INJURY; OXIDATIVE STRESS; OBSTRUCTIVE-JAUNDICE; ISCHEMIA/REPERFUSION INJURY; ISCHEMIA-REPERFUSION; SATIETY MOLECULE; CELL APOPTOSIS; ACETIC-ACID; NUCB2/NESFATIN-1;
D O I：
10.2147/JIR.S273446
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Nesfatin-1, a newly identified energy-regulating peptide, is widely expressed in the central and peripheral tissues, and has a variety of physiological activities. A large number of recent studies have shown that nesfatin-1 exhibits antioxidant, anti-inflammatory, and anti-apoptotic properties and is involved in the occurrence and progression of various diseases. This review summarizes current data focusing on the therapeutic effects of nesfatin-1 under different pathophysiological conditions and the mechanisms underlying its antioxidant, anti-inflammatory, and anti-apoptotic activities.
引用
收藏
页码：607 / 617
页数：11
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