HIF-I and tumour radiosensitivity

被引：156

作者：

Moeller, B. J. ^{[1
]}

Dewhirst, M. W. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA

来源：

BRITISH JOURNAL OF CANCER | 2006年 / 95卷 / 01期

关键词：

HIF-I; tumour; vessel; radiosensitivity;

D O I：

10.1038/sj.bjc.6603201

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity.

引用

页码：1 / 5

页数：5

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