Stereoisomer quantification of the β-blocker drugs atenolol, metoprolol, and propranolol in wastewaters by chiral high-performance liquid chromatography-tandem mass spectrometry

被引：133
作者：
Nikolai, Lisa N. [1 ]
McClure, Evelyn L. [1 ]
MacLeod, Sherri L. [1 ]
Wong, Charles S. [1 ]
机构：
[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada
来源：
JOURNAL OF CHROMATOGRAPHY A | 2006年 / 1131卷 / 1-2期
基金：
加拿大自然科学与工程研究理事会;
关键词：
chiral HPLC-MS-MS; beta-blockers; wastewater; enantionters;
D O I：
10.1016/j.chroma.2006.07.033
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A chiral liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) method was developed and validated for measuring individual enantiomers of three P-blocker drugs (atenolol, metoprolol, and propranolol) in wastewater treatment plant (WWTP) influents and effluents. Mean recoveries of the pharmaceuticals ranged from 67 to 106%, and the limits of detection of the analytes were 2-17 ng/L in wastewater effluents. The method was demonstrated by measuring, for the first time, the stereoisomer composition of target analytes in raw and treated wastewaters of two Canadian WWTPs. In these trials, racemic amounts of the three drugs were observed in influent of one wastewater treatment plant, but nonracemic amounts were observed in another. Effluents of the two plants contained nonracemic amounts of the drugs. These results indicate that biologically-mediated stereoselective processes that differ among WWTPs had occurred to eliminate individual enantiomers of the target analytes. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：103 / 109
页数：7
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