Evaluation of left ventricular mass on cadmium-zinc-telluride imaging: Validation against cardiac magnetic resonance

BackgroundSingle-photon emission computed tomography has shown relevant limitations in the quantification of left ventricular (LV) mass. We sought to compare the estimates of LV mass on Cadmium-Zinc-Telluride (CZT) myocardial perfusion imaging (MPI) as compared to cardiac magnetic resonance (CMR).Methods and resultsTwenty-five patients underwent MPI on a CZT camera and CMR on a 1.5 T scanner within 123weeks. LV mass was quantified on CZT images using two softwares: 4D-MSPECT (4DM) and Emory Cardiac Toolbox (ECTb). LV mass by CMR was quantified using MASS software (Medis, Leiden, The Netherlands). LV mass values obtained with 4DM and ECTb were highly reproducible [intraclass correlation coefficients .98 (95% CI .97-.99), and .98 (95% CI 0.97-.99), respectively]. The mean LVM mass values were 151 +/- 44g on CMR, 151 +/- 43g with 4DM (P=NS vs CMR), and 157 +/- 42g with ECTb (P<.001 vs CMR; P=.007 vs 4DM) CZT images. There was an excellent correlation between LV mass values between CMR and both 4DM (R-2=.95; P<.001) and ECTb (R-2=.98; P<.001) with narrow limits of agreement (-13.6% to +13.4% for 4DM, and -5.6% to +14.1% for ECTb).Conclusionsp id=Par3The evaluation of LV mass is feasible on CZT images, showing excellent agreement with CMR.