Synthesis, Crystal Structure and Antifungal Activity of 2-((2-Fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole

被引：0
作者：
Sun Guo-Xiang [1 ]
Shi Yan-Xia [3 ]
Zhai Zhi-Wen [2 ]
Sun Zhao-Hui [2 ]
Weng Jian-Quan [2 ]
Tan Cheng-Xia [2 ]
Liu Xing-Hai [2 ]
Li Bao-Ju [3 ]
机构：
[1] Yancheng Inst Technol, Sch Chem & Chem Engn, Yancheng 224051, Jiangsu, Peoples R China
[2] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China
[3] Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100014, Peoples R China
来源：
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2016年 / 35卷 / 12期
关键词：
oxadiazole compound; synthesis; crystal structure; antifungal activity; ONE-POT SYNTHESIS; BIOLOGICAL-ACTIVITY; DERIVATIVES; 1,3,4-THIADIAZOLE; FACILE; DESIGN; DFT;
D O I：
10.14102/j.cnki.0254-5861.2011-1352
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The title compound 2-((2-fluorobenzyl) thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole (C14H10FN3OS) was synthesized, and its structure was confirmed by H-1 NMR, MS, elemental analyses and X-ray diffraction. It crystallizes in the monoclinic system, space group P2(1)/n with a = 11.541(16), b = 8.226(12), c = 13.683(19) angstrom, beta = 94.872(17)degrees, V = 1294(3)angstrom(3), Z = 4 and R = 0.0648 for 2198 observed reflections with I > 2s(I). The preliminary biological test shows that the title compound has good activity against Pythium ultimum with inhibitory to be 100%.
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收藏
页码：1855 / 1859
页数：5
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